Manual

Appendix - 11
Page 80 14439.C 03/2013VerifyNow System User Manual | USA
Term Description
Detection well
The detection wells of an test device contain a lyophilized preparation of human
brinogen coated beads and platelet agonist. The instrument measures platelet
aggregation as an increase in light transmittance through the detection wells.
Diluent An optically absorbent solution used in lieu of blood during wet quality control.
Diluent tube Tube in the VerifyNow Assay WQC kit (part number 85047) containing the diluent.
Discard tube
When collecting patient samples using direct venipuncture, the discard tube (that
islaterdiscarded)islledbeforethesampletube.Thistubemaybeplainsodium
citrate, blood culture, or heparin tube. The tube cannot contain EDTA (purple top).
Electronic
quality control
Electronic quality control (EQC) is a procedure during which the software will
calibrate and verify instrument optics performance, reagent mixing, and instrument
pneumatics.
EQC See electronic quality control.
EQC device
A re-usable device that is inserted by the operator into the test port and is used
toperformacomprehensivetestingroutinethatconrmsperformanceofkey
instrument components.
EQC frequency
SpeciesthetimeintervalbetweenEQC tests. When the time interval is exceeded,
the instrument cannot perform patient testing until an EQC test is performed.
Eptibatide
Eptibatide(tradenameIntegrilin
®
) is a platelet aggregation inhibitor mainly used
during and after coronary artery procedures like angioplasty to prevent thrombus
(blood clot) formation within the coronary artery. Its mechanism of action is
inhibition of the glycoprotein IIb/IIIa complex.
Error
A type of message that displays after an unexpected event. Typically these events
occur when the instrument detects an abnormal condition, and often can be
corrected by the customer.
F1
Themixerfrequencyagcountparameter reported during electronic quality control
diagnostics. See electronic quality control.
F2
The mixer frequency transitions (high to low) parameter reported during electronic
quality control diagnostics. See electronic quality control.
Fibrinogen
Asolublebloodplasmaproteinwhichtheenzymethrombinconvertsintobrin
during the blood-clotting process. The binding of the activated platelet IIb/IIIa
receptorstobrinogen (and vWF) results in the formation of platelet-platelet and
platelet-matrix adhesive interactions and the formation of a stable, larger platelet
aggregate.
glycoprotein
(GP) IIb/IIIa
receptor
Activation induces a conformational change in the platelet glycoprotein IIb/IIIa
receptorsonthesurfaceofplateletstoanactivatedhigh-afnitybindingsitefor
brinogen and vWF. The binding of the activated platelet IIb/IIIa receptors to
brinogen(andvWF)results in the formation of platelet-platelet and platelet-matrix
adhesive interactions and the formation of a stable, larger platelet aggregate at the
site of injury.
Icon
Icons are used to navigate through the steps in a test. Icons display along the right
side of the display screen and correspond to an adjacent icon key.
Icon keys
The four icon keys directly to the right of the display screen correspond to the
different icons displaying on the screen. Selecting an icon key displays another
screen or directs the instrument to perform an action.