Manual

Page 81 14439.C 03/2013
Appendix - 11
VerifyNow System User Manual | USA
Term Description
Inhibitor,
glycoprotein
(GP) IIb/IIIa
GP IIb/IIIa inhibitorsblockplateletaggregationbypreventingbrinogen and other
adhesion molecules (vWF) from binding to the IIb/IIIa integrin on platelets.
Integrilin
Eptibatide(tradenameIntegrilin
®
) is a platelet aggregation inhibitor mainly used
during and after coronary artery procedures like angioplasty to prevent thrombus
(blood clot) formation within the coronary artery. Its mechanism of action is
inhibition of the glycoprotein IIb/IIIa complex.
iso-TRAP
Thrombin receptor activating peptide (iso-TRAP), a synthetic peptide, serves as a
surrogate for thrombin and activates the platelet through the PAR-1 receptor in the
and IIb/IIIa Test.
Keypad
The keypad contains 13 labeled keys located directly below the display screen.
The“0”through“9”keysareusedtoenteroperatorandpatientidentication
numbers, change the time and the date, and make selections from menu options.
Level 1
Wet quality control Level 1 is formulated at a clinically relevant level and is
representative of a sample with platelet inhibition. During Level 1 WQC, diluent is
used to verify continued performance by checking that actual results are within a
standard range. See also wet quality control.
Level 2
WQC Level 2 is formulated at a clinically relevant level, and is representative of
a sample with no platelet inhibition. During Level 2 WQC, a pink pellet is added
to the diluent to verify continued performance, by checking that actual results are
within a standard range. See also wet quality control.
Log
A running record of activity by the instrument. There are separate logs organized
by patient results, QC results, and error events.
Mask
The optical element parameter reported during electronic quality control
diagnostics. See electronic quality control.
Mode
The instrument supports two modes, depending on whether the instrument is
running a test or QC test.
Operator
identication
A feature that assigns a number and matching password number to each operator.
Whenenabled,identication is required to use the instrument.
P1
The maximum pressure level parameter reported during electronic quality control
diagnostics. See electronic quality control.
P2Y12 reaction
units
PRU. PRU reports the amount of ADP-mediatedaggregationspecictotheplatelet
P2Y12 receptor, and is calculated as a function of the rate and extent of platelet
aggregation in the ADP channel.
P2Y12 receptor
The P2Y12 receptor is a G protein-coupled P2 receptor on the surface of the
platelet. Adenosine diphosphate (ADP) secreted from activated platelets results in
thefurtheramplicationbyactivatingadditionalplateletsincirculationviatheP2Y1
and P2Y12 receptors.
PAR-1 receptor
PAR-1 is one of four protease-activated receptors (PAR) located on the surface of
platelets. Thrombin activates PAR-1 by cleavage of part of its extracellular domain.
Thrombin receptor activating peptide (iso-TRAP), a synthetic peptide, serves as a
surrogate for thrombin and activates the platelet through the PAR-1 receptor in the
PRUTest, P2Y12 and IIb/IIIa tests.