Manual

Appendix - 11
Page 82 14439.C 03/2013VerifyNow System User Manual | USA
Term Description
PAR-4 receptor
PAR-4 is one of four protease-activated receptors (PAR) located on the surface of
platelets. Thrombin activates PAR-4 by cleavage of part of its extracellular domain.
PAR-4 activating peptide (PAR-4 AP), a synthetic peptide, serves as a surrogate
for thrombin and activates the platelet through the PAR-4 receptor in the VerifyNow
PRUTest.
PAR-4 activating
peptide
PAR-4 activating peptide (PAR-4 AP), a synthetic peptide, serves as a surrogate
for thrombin and activates the platelet through the PAR-4 receptor in the VerifyNow
PRUTest.
Password
Whenoperatoridenticationisenabled,auseridenticationnumberanda
matching password number are required to use the instrument.
Patient
Identication
Afeaturethatassignsapatientidentication (ID) to each patient sample.
PAU See platelet aggregation units.
Pellet
A hygroscopic substance provided in the WQC kit and used in Level 2 wet quality
control testing. The active ingredient is a peptide that gives results that mimic
platelet function in an uninhibited sample.
Percent
inhibition
Percent inhibition(%)isthepercentchangefrombaselineaggregation,andis
calculated from a result and a baseline result (for IIb/IIIa Test only).
PGE1
The VerifyNow PRUTest uses PGE1 to increase intraplatelet cAMP and reduce the
contributionoftheP2Y1receptoronactivation.Thismakesthetestmorespecic
for the effects of ADP on the P2Y12 receptor.
Platelet
Also called a thrombocyte. A discoid cell found in large numbers in blood,
responsible for aggregation and contributing to haemostasis by repairing vascular
wall injuries.
Platelet
activation
Platelet activation induces a conformational change in the platelet glycoprotein IIb/
IIIa receptorsonthesurfaceofplateletstoanactivatedhigh-afnitybindingsitefor
brinogen and vWF. The platelet changes from a disc shape to a round shape with
long,lopodialextensionsthatcanbindtoadhesiveproteinsincirculation,suchas
brinogen,toformameshworkofplatelets.
Platelet
aggregation
units
The IIb/IIIa test reports patient results in Platelet Aggregation Units (PAU). PAU is
calculated as a function of the rate and extent of aggregation.
Platelet function
test
A laboratory or point-of-care test to measure platelet activity or platelet inhibition
in patients. One method detects platelet activity by measuring in vitro platelet
aggregationinabloodsampleexposedtospecicagonists.
Platelet
inhibition
The condition in which or the process by which platelet aggregation is inhibited.
Platelet inhibition may be induced in response to a potent anti-platelet agent (e.g.
acetylsalicylic acid (aspirin), P2Y12 inhibitors, and GP IIb/IIIa inhibitors).
Plavix
Clopidogrel (trade name Plavix
®
- clopidogrel bisulfate) is a potent oral antiplatelet
agent used in the treatment of coronary artery disease, peripheral vascular
disease, and cerebrovascular disease. As a thienopyridine, its mechanism of
action is inhibition of the P2Y12 receptor.
Prasugrel
Prasugrel(tradenameEfent)isanovelantiplateletagentusedinthetreatment
of patients with acute coronary syndromes. As a thienopyridine, its mechanism of
action is inhibition of the P2Y12 receptor.