SDS

10
CONTINUED: SECTION 11. TOXICOLOGICAL INFORMATION
- Copper : In maximization test on skin sensitization with guinea pig, skin sensitization was not observed. (OECD TG 406, GLP)
- Dimethyl carbonate : In the skin sensitization test using guinea pig, this material was not skin sensitizing. (OECD Guideline 406,
GLP)
- Aluminum : In test with guinea pigs, it can be concluded that aluminium oxide has no sensitisation potential under the experimental
conditions. (Read across; Aluminium oxide)
- Polyethylene : No reactions were observed in skin sensitization test with guinea pigs.
- 1,3-Dioxolan-2-one : In the skin sensitization test using guinea pig, this material was not classified. (OECD Guideline 406, GLP)
- Lithium hexafluorophosphate(1-) : In the skin sensitization test using mice, the test material was not skin sensitization. (OECD
Guideline 429, GLP)
- Ethyl acetate : In the skin sensitization test using guinea pig, this material was not skin sensitizing. (OECD Guideline 406)
- Carbon black : In skin sensitization test with guinea pig, it did not induce skin sensitization. (OECD TG 406, GLP)
- Nickel; Raney nickel : Nickel hypersensitivity dermatitis may be initiated by contact with nickel on the skin.
- Lithium carbonate;Lithane : In the skin sensitization test using guinea pig, this material was not skin sensitizing. (OECD Guideline
406, GLP)
- 1-Methyl-2-pyrrolidinone : In the skin sensitization test using mice, the test material was not skin sensitization. (OECD Guideline
429, GLP)
Carcinogenicity :
IARC
- Nickel : Group 2B
- Cobalt and cobalt compounds : Group 2B
- Polyethylene : Group 3
- Carbon black : Group 2B
NTP
- Nickel : R
- Iron : Present
OSHA
- Nickel : Present
ACGIH
- Nickel : A5
- Cobalt and cobalt compounds : A3
- Aluminum : A4
- Carbon black : A3
KOREA-ISHL
- Cobalt and inorganic compounds : 2
- Carbon black : 2
- Nickel : 1A
EU
- Lithium nickelate : Carc.1A
- Nickel : Carc.2
- Copper : EPA IRIS: D In carcinogenicity study with rat, tumor was not observed.
- Polyethylene : Fifty rats were implanted with polyethylene. In the polyethylene group, 23 developed tumors (two of these were
unrelated to the implants).
Mutagenicity :
-Graphite : Negative reactions were observed in vitro (Bacterial Reverse Mutation Assay(OECD Guideline 471, GLP)).
- Fe : In mammalian cell gene mutation assay electrolytic iron, positive carbonyl iron exhibited a cytotoxic and mutagenic response
(OECD TG 476)
- Copper : Negative reactions were observed in both in vitro(Ames test) and in vivo(DNA damage and/or repair; unscheduled DNA
synthesis, micronucleus assay). (GLP)
- Dimethyl carbonate : Negative reactions were observed in both in vitro (Mammalian Chromosome Aberration Test (OECD
Guideline 473, GLP)) and in vivo (Mammalian Spermatogonial Chromosome Aberration Test (OECD Guideline 483))
- Aluminum : Negative reactions were observed in vitro (mammalian cell gene mutation assay with mouse lymphoma L5178Y
cells(OECD TG 476, GLP)) and in vivo (micronucleus assay with rats (OECD TG 474, GLP)). (Aluminium hydroxide, aluminium
chloride, aluminum oxide; read across)
- Polyethylene : Negative reactions were observed in Ames test using Salmonella typhimurium and Escherichia coli.