SDS

9
CONTINUED: SECTION 11. TOXICOLOGICAL INFORMATION
- Ethyl acetate : Rabbit LD
50
＞
20,000 mg/kg (male)
- Lithium carbonate;Lithane : Rabbit LD
50
＞
3,000 mg/kg (male/female) (OECD Guideline 402)
-1-Methyl-2-pyrrolidinone : Rat LD
50
＞
5,000 mg/kg (male/female) (OECD Guideline 402)
Inhalation :
- Graphite : Rat LD
50
＞
2 mg/L/4hr (male/female) (OECD Guideline 403)
- Fe : Rat LC
50
＞
100 mg/m³/6hr
- Dimethyl carbonate : Rat LD
50
＞
5.36 mg/L/4hr (male/female) (OECD Guideline 403)
- Aluminum : Rat LC
50
＞
0.888 mg/L/4hr (analytical) (OECD TG 403)
- 1,3-Dioxolan-2-one : Rat LC
0
= 730 mg/m³ /8hr
- Ethyl acetate : Rat LCL
0
＞
6000 ppm (male/female)
- Carbon black : Rat LC
50
＞
0.005 mg/L/4hr
- Lithium carbonate;Lithane : Rat LC
50
＞
2 mg/L/4hr (male/female) (OECD Guideline 403)
- 1-Methyl-2-pyrrolidinone : Rat LC
50
＞
5.1 mg/L/4hr (male/female) (OECD Guideline 403)
Skin corrosion/ irritation :
-Graphite : In the skin irritation test using rabbits, the test material was not irritating. (OECD Guideline 404, GLP)
-Fe : In test on skin irritation with rabbits, skin irritations were not observed.(Read across; Fe3O4)(OECD TG 404, GLP)
-Copper : In test on skin irritation with rabbits, skin irritations were not observed. (OECD TG 404, GLP)
-Dimethyl carbonate : In the skin irritation test using rabbits, the test material was not irritating. (OECD Guideline 404)
-Aluminum : Aluminium oxide caused slight erythema in 2/12 rabbits. The observed effects do not lead to a classification. Aluminium
oxide is, therefore, not considered to be a primary skin irritant.(OECD TG 404)(Read across; aluminium oxide)
-Polyethylene : No irritation was observed at the other two treated sites and no corrosive effects were noted during the study using
rabbits. The primary irritation index was calculated as 0.2 and polyethylene was classified as a mild irritant.
-1,3-Dioxolan-2-one : In the skin irritation test using rabbits, the test material was not classified. (OECD Guideline 404, GLP)
-Lithium hexafluorophosphate(1-) : In the skin irritation test using human, the test material was corrosive. (EU Method B.40, GLP)
-Ethyl acetate : In the skin irritation test using rabbits, the test material was slightly irritating. (OECD Guideline 404)
-Carbon black : In test on skin irritation with rabbits, skin irritations were not observed. (OECD TG 404)
-Nickel; Raney nickel : Industrial nickel dust causes nickel dermatitis.
-Lithium carbonate;Lithane : In the skin irritation test using rabbits, the test material was not irritating. (OECD Guideline 404, GLP)
-1-Methyl-2-pyrrolidinone : In the skin irritation test using rabbits, the test material was slightly irritating. (OECD Guideline 404,
GLP)
Serious eye damage/ irritation :
- Graphite : In the eye irritation test using rabbit, the test material was not irritating. (OECD Guideline 405, GLP)
- Fe : In test on eyes irritation with rabbits, eyes irritations were not observed.(Read across; Fe3O4)(OECD TG 405, GLP)
- Copper : In test on skin irritation with rabbits, skin irritations were not observed. (OECD TG 405, GLP)
- Dimethyl carbonate : In the eye irritation test using rabbit, the test material was not irritating. (GLP)
- Aluminum : An eye irritation study of the aluminium oxide was performed in rabbits. No eye irritation/ corrosion effects were
observed. (Read across; aluminium oxide)
- Polyethylene : Mild irritants were observed in eye irritation test with rabbits. (Score 11.7/110)
- 1,3-Dioxolan-2-one : In the eye irritation test using rabbit, the test material was moderately irritating. (OECD Guideline 405, GLP)
- Lithium hexafluorophosphate(1-) : In the eye irritation test using fertilised brown leghorn chicken eggs, the test material was verely
irritating. (GLP)
- Ethyl acetate : In the eyes irritation test using rabbits, the test material was not irritating. (OECD Guideline 405)
- Carbon black : In test on eyes irritation with rabbits, eyes irritations were snot observed. (OECD TG 405)
- Lithium carbonate;Lithane : In the eye irritation test using rabbit, the test material was moderately irritating. (OECD Guideline 405
GLP)
- 1-Methyl-2-pyrrolidinone : In the eye irritation test using rabbit, the test material was moderately irritating. (OECD Guideline 405,
GLP)
Respiratory sensitization :
-Aluminum : Al2O3 was the least inflammatory material tested and led to only weak effects on the mouse lung. (Read across;
Aluminium oxide)
-Carbon black : In respiratory sensitization test with mice, it did not induce respiratory sensitization.
Skin sensitization :
- Graphite : In the skin sensitization test using mice, the test material was not skin sensitization. (OECD Guideline 429, GLP)
- Fe : In the test using guinea pigs, the test substance was not considered to be a dermal sensitizer in guinea pigs.(read across; FeO,
Fe2O3)