SDS

NEONIX Co., Ltd.
Date: Feb 22, 2022
MODEL VCA-RBT95 / DJ96-00234A
Reproductive toxicity :
- Copper : In reproductive toxicity with rats, there were no effects considered (up to 1500 ppm).
(OECD TG 416, GLP)
- Aluminum : No reproduction, breeding and early post-natal developmental toxicity was observed in rats at
1000 mg/kg bw for males and females. (OECD TG 422, GLP)(Aluminium chloride; read across)
- Lithium hexafluorophosphate(1-) : In the two-generation reproductive toxicity with rats, no effects
observed on reproductive toxicity. (male/female)(OECD Guideline 416, GLP)(OECD Guideline
414)(Information on major hydrolysis product of the registered substance (released rapidly on contact with
water/moisture))
- Carbon black : No adverse effects on the reproductive function are expected.(OECD TG 414)
Specific target organ toxicity (single exposure) :
- Fe : If inhaled, iron is a local irritant to the lung and gastrointestinal tract.
- Copper : All animals showed expected gains in bodyweight over the study period and there were no
abnormalities noted at necropsy. (OECD TG 423, GLP)
- Aluminum : In test using rats, Clinical signs of depression, laboured respiration, piloerection and hunched
appearance was noted at the highest dose 15900 mg/kg. Macroscopic examination at the end of the
observation period did not reveal any aluminium-related changes of the internal organs of the aluminium
treated animals compared to the control group. (OECD TG 401)(Fumed alumina; read across)
- Polyethylene : No test substance-related toxic effects were observed in an acute oral toxicity study with
rats.
- Lithium hexafluorophosphate(1-) : Clinical signs observed during the study period were lethargy, hunched
posture, uncoordinated movements, piloerection at 300 mg/kg, hunched posture, piloerection at 50
mg/kg. The surviving animals had recovered from the symptoms by Day 3.(OECD Guideline 423,
GLP)
- Carbon black : No effect on endothelins or blood pressure was observed after exposure to carbon black.
There were also no effects on body temperature and activity of the animals.
- Nickel; Raney nickel : In the acute oral toxicity using rat, there were no effects on clinical signs, systemic
toxicity.(OECD Guideline 401, GLP)
Specific target organ toxicity (repeat exposure) :
- Fe : Rats were exposed to metallic iron as carbonyl iron via their feed (2.5%) for 2, 4, 6, or 9 weeks.
This resulted in a strong increase of non-heme iron in the liver and clear lipid peroxidation in the liver and
the mucosa of the duodenum. No evidence for DNA breakage were found. What follows is the original
abstract of the publication. (carbonyl iron)
- Copper : In test with rats for 92 days, there were no mortalities or signs of clinical toxicity observed in any
of the test species during the duration of the study. Opthalmoscopic examinations revealed no
abnormalities at any dose level tested. At gross pathology, significant decreases in heart and kidney weight
were noted in the high dose males in the thymus and kidneys of high dose females. (GLP)
- Aluminum : On occasion workers chronically exposed to aluminum-containing dusts or fumes have
developed severe pulmonary reactions including fibrosis, emphysema and pneumothorax.
- Polyethylene : No significant adverse effects were observed in subchronic (90-day) oral toxicity study with
rats and dogs.
- Lithium hexafluorophosphate(1-) : According to expert review of fluoride intake and effects on human
health, fluoride intake in drinking water at levels close to or above 4 mg/l is associated with dental fluorosis
and perhaps also bone fluorosis and/or weakening.; Damage to dental enamel recorded: especially notable
in young animals, which also showed atrophy of respiratory organs/tissues with local oedema of bronchial
mucosa. Older animals showed peribronchial hyperplasia. Animals around 1 year in age showed cavity
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