Specifications
pGolidinemethanol
1
-na~hthaleneethanol
I
Aldrich
I
FW 172.23
1
206
mg
Material
ArgoCaps (PS-DES)
Wilkinson's catalyst
Chlorotris(triphenylphosphine)
rhodium(1) (RhC1(PPhj);
Source
Argonaut
Strem
Comment
I
Total amount used
I
1
50 mg/capsule,
-0.68
mmollg*
FW
925.23
1 -(2-methoxybenzoy1)-2
1
Aldrich
I
FW
235.28
1
282 mg
2,2-dipheny lethanol
Epiandrosterone
4-biphenylcarboxaldehyde
HFiwridine
Table
1.
Solvents and Reagents Needed for the Quest
210
Tutorial
10
capsules supplied
with
the Quest 2 10
76 mg
.
-
Methoxytrimethylsilane (MeOSiMe;)
1-Methyl-2-pyrrolidinone,
anhydrous
(NMP)
Pyridine, anhydrous
Tetrahydrofuran,
anhydrous
(THF)
Dichloromethane,
anhydrous
(DCM)
Quest
2
10 Synthesizer. Syntheses should be performed in the reaction vessels as shown
in
Table
2.
Polystyrene-Diethylsilane
linker (PS-DES resin) encapsulated in
Aldrich
Aldrich
Aldrich
Aldrich
RV number Diversity Reagent Structure
1,6
1
-(2-methoxybenzoy1)-2-
pyrrolidinemethanol
*
Due to lot differences in the PS-DES resin, the amount of solvents and reagents required for this tutorial may
be different from the amounts shown in Table
1.
Refer to Figure
1
and the lot information supplied with the
PD-DES ArgoCaps to calculate the materials necessary for your synthesis.
Aldrich
Aldrich
Aldrich
Fisher
Fisher
~h'
L~~
4,
9
epiandrosterone
FW 198.27
FW 290.45
FW 182.22
-70%
HF,
Table
2.
Quest
210
Tutorial Reaction Vessel Set
Up
-
238 mg
348 mg
218 mg
0.4 mL
-30% pyridine
FW 104.23,
d
=
0.756
99.5% Dried over
molecular sieves
Sure-seal
HPLC grade
Stored under
N2
HPLC grade
Stored under NZ
Argonaut Technologies
Part
Number 102298
5.0 mL
220 mL
0.8 mL
210
mL
240 mL
04/02/98
Quest Tutorial
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