Artisan Technology Group is your source for quality new and certified-used/pre-owned equipment • FAST SHIPPING AND DELIVERY • TENS OF THOUSANDS OF IN-STOCK ITEMS • EQUIPMENT DEMOS • HUNDREDS OF MANUFACTURERS SUPPORTED • LEASING/MONTHLY RENTALS • ITAR CERTIFIED SECURE ASSET SOLUTIONS SERVICE CENTER REPAIRS Experienced engineers and technicians on staff at our full-service, in-house repair center WE BUY USED EQUIPMENT Sell your excess, underutilized, and idle used equipment We also offer credit for buy-back
QUESTGASEOUS REACTION AND CONCENTRATION MANIFOLD PN 103952 Rev 1.0 28 October 1999 Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.
Quest" Gaseous Reaction & Concentration Manifold - User Manual Part Number 103952 Revision 1.0 28 October 1999 Copyright 0 1999 by Argonaut Technologies All rights reserved. Argonaut Technologies 887 Industrial Rd., Suite G San Carlos, C A 94070 Printed in the United States. The information in this document has been carefully checked and is believed to be entirely reliable. However, no responsibility is assumed for inaccuracies.
Limited Warranty All individual instrument parts, consumables and the like are subject to the provisions of the Seller Limited Ninety (90) Days Warranty as outlined below. Resin consumable products or the like are only warranted to conform to the quantity and content stated on the label at the time of delivery.
INCIDENTAL DAMAGES, HOWEVER CAUSED A N D O N A N Y THEORY O F LIABILITY, ARISING IN A N Y WAY O U T O F T H E SALE AND/OR LICENSE O F PRODUCTS OR SERVICES T O BUYER. THIS LIMITATION S H A L L APPLY EVEN IF SELLER HAS BEEN ADVISED O F T H E POSSIBILITY O F S U C H DAMAGES A N D NOTWITHSTANDING ANY FAILURE O F ESSENTIAL PURPOSE O F A N Y LIMITED REMEDY. Exclusions This limited warranty covers normal use.
Warranty Argonaut Warranty Agreement Limited Warranty Limitation of Liability Exclusions Contents Introduction Overview Interference Information Year 2000 Software and Firmware Compliance Safety User Attention Words Warning Labels System Safety Safety Equipment Operating Environment R V Sealing Capabilities Material Safety Data Sheets (MSDS) GRCM Installation List Of Parts Components and Parts Supplied by Argonaut GRCM - User Manual Artisan Technology Group - Quality Instrumentation ...
Parts Supplied by User Overview Installation Steps Control Box Gas Delivery Manifold Solvent Trap Manifold Expansion Kit Gas Delivery Manifold Solvent Trap Manifold 4 Using the GRCM Hydrogenation Concentration By Evaporation Cleaning the G R C M Gas Delivery Manifold Using the Quest 210 Using the Quest ASW Female Luers on the Quest Lower Manifold A Service Contact Information B List Of Components Basic G R C M Expansion Kit Index GRCM - User Munuul Artisan Technology Group - Quality Instrumentation .
OVERVIEW 1 1 # # 1 l 1 # 1 1 1 1 # 1 1 1 1 1 1 1 # l l # 1 ~ # I I I # I # I I I I # # 1 1 1 8 1 1 # 1 ~ ~ # 1 # The QuestTMGaseous Reaction and Concentration Manifold ( G R C M ) is designed for use on the Quest 210 S L N organic synthesizer, and on the standard Quest 210 with the Lower Manifold Luer Upgrade. The GRCM enables gaseous reactions (e.g., hydrogenation, carbonylation, etc.) and sparging to be to be carried out.
INTERFERENCE INFORMATION 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I I I I 1 1 I I 1 a I 1 I I I I I I I $ I m I 1 I I l 1 1 1 I , This equipment does not generate or use radio frequency energy. YEAR 2000 SOFTWARE AND FIRMWARE COMPLIANCE 1 1 l 1 I l 1 I 1 I f 1 I 1 1 I I 1 I I 1 I l I I 1 I I I I I 1 I I I I I I I I 1 I I 1 I I I I 1 1 1 I The Gaseous Reaction and Concentration Manifold has no related software or firmware.
T his chapter discusses safety issues related to the operation and use of the Quest Gaseous Reaction and Concentration Manifold (GRCM) when used in conjunction with a Quest 2 1 0 SLN o r a Quest 210 with the Lower Manifold Luer Upgrade. Please read it carefully before attempting to operate the system. /F\ Warning! - This chapter only discusses safety issues related to the Quest Gaseous Reaction and Concentration Manifold (GRCM).
SAFETY Warning Labels A Warning! This word informs the users that physical injury or death could occur to themselves or others if the required precautions are not taken. Warning labels are applied to the equipment in specific areas where the user must observe safety precautions. Following is a list of these labels and their meanings: Label This symbol indicates a hot surface. Use caution when working on or near locations with this symbol. Picture Caution! Hot Surface Earth ground.
' SAFETY System Safety . SYSTEM SAFETY I I I I I I I t I I I 1 I I I B I 1 I 1 I I I I E I I I I I I I I I I I I I I I I I l B I I I I I I I l During operation of the G R C M , hazardous chemicals are stored and manipulated, heavy objects shake and move, and high voltage electricity is present. Caution must be exercised by trained personnel a t all times.
We recommend that the following safety equipment be readily available during instrument operation: fire extinguisher, eye wash station, safety shower, eye and hand protection, adequate ventilation, and protection from sources of radiation (e.g. lasers, radioisotopes, contaminated equipment, radioactive waste). A Warning! If the equipment is used in a manner not specified by the manufacturer, the protection provided by the equipment may be impaired.
SAFETY RV Sealing Capabilities ' . R V SEALING CAPABILITIES 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ~ 1 ~ 1 1 # 1 1 1 1 ~ 1 1 1 1 1 1 1 1 1 1 1 1 1 1 The GRCM has been tested and validated in the following operational conditions. Argonaut does not recommend operation of the G R C M in environmental conditions outside these ranges. Operational Requirement Reaction Vessel sealing, with Gas Delivery Manifold installed. Specification 10 psig (1.
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G R C M INSTALLATION T his chapter describes the Quest Gaseous Reaction and Concentration Manifold (GRCM) and how it is installed by the user. Installation of the Expansion Kit (available separately) is described at the end of this chapter. COMPONENTS A N D P A R T SSUPPLIEDB Y ARGONAUT The GRCM consists of the following components: Control Box - Controls which of the two gas inputs is used and regulates the gas flow rate from the selected input to the Quest Reaction Vessels (RVs).
Two plugs: for the "T" when the gas manifold is not in use, and for the Gas Out B port when the Expansion Kit is not in use (part number 100083) 114 inch ID tubing for solvent trapping, 3 feet (part number 103954) Barbed fitting adapter (114 - 318 inch) for solvent trap (part number 103669) I I Figure 1: GRCM - Three Main Components P A R T SSUPPLIEDB Y USER The user must provide the following items: An external gas tank for gaseous reagents, with a 0-30 psig (1.01-3.
GRCM INSTALLATION Overview ,A Caution Do not use corrosive gases, e.g., hydrogen chloride, ammonia, or ozone with the GRCM. Using corrosive gases will damage the GRCM and void the warranty. OVERVIEW 1 1 1 1 1 1 1 1 l 1 1 1 1 1 l 1 1 1 1 I I I I l I I I I 1 I I I I I I I I I I s l l l I t l l l l l l l The Control Box fits neatly on the top of the Quest controller. It must be placed within four feet of the external reagent gas tank, and within four feet of the Quest 210 Reactor.
INSTALLATION STEPS 1 1 1 1 1 1 1 1 1 1 1 l 1 1 1 1 1 1 1 1 I I I I I I I I I I D I I D I I 1 I I I # a t l 1 l l 1 l 1 1 1 Control Box 7 GRCM Control Box I Quest 210 I Installation Outlets Umbilical Line 3 Inert Gas Extension Line Part Number 300796 Figure 2: GRCM Control Box Installation 1. On the front of the Quest controller, locate the ports for the five 118 inch Teflon lines from the Reactor Umbilical. 2. Remove the line from port #3 by unscrewing the 118 inch PEEK fitting.
GRCM INSTALLATION Installation Steps 3. Attach the end of that line to side B of the "T" (Part number 101955) and make it finger-tight. 4. lnsert one end of the lnert Gas Extension Line (Part number 300797) into side A of the "T" and make finger-tight. lnsert the other end of the line into port #3 of the Quest controller and make finger-tight. 5. Attach one end of the lnert Gas Inlet Line (Part number 300795) to side C of the "T". Connect the other end to input 1 of the GRCM Control box.
Gas D e l i v e r y Manifold 1. Connect one end of the Gas Delivery Manifold line (Part number 300794) to the outlet of the GRCM control box. Connect the other end to the inlet port of the Gas Delivery Manifold. Install a plug on the other outlet of the GRCM Control Box if it is not being used. 2. Push in the two buttons on the waste tray handles and lower the waste tray. 3. Remove the waste container and set it aside. 4. Select the side of the Quest reactor which you will be using. 5.
GRCM INSTALLATION Installation Steps A ' . Quest Lower Manifold with Gas Delivery Manifold in the Waste Tray Lower Gas Rail Lev aste aY UP B Quest Lower Manifold with Gas Delivery Manifold Installed Figure 4: Gas Delivery Manifold and the Quest Lower Manifold Solvent Trap Manifold The installation of this component is required for concentration by evaporation. 1. Remove the h e r plugs from the upper manifold of the reaction bank which you will be using. 2.
Figure 5 on the following page shows a schematic of the Quest Upper Manifold with the Gas Delivery Manifold separated and fitted. A B Pnnnertinn Quest Upper Manifold and Solvent Trap Manifold Separated Solvent Trap Manifold Fitted to Quest Upper Manifold Figure 5:Solvent Trap Manifold and the Quest Upper Manifold G R C M - U s e r Manual Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.
GRCM INSTALLATION Installation Steps Figure 6: The Gas Delivery Manifold Installed Figure 7: Gas Delivery and Solvent Trap ManifolIds Installed GRCM - U s e r Manual Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.
This Expansion Kit enables reactions and concentrations to be carried out on all twenty reaction vessels in the Quest 210 synthesizer. It consists of a Gas Delivery Manifold and a Solvent Trap Manifold with the necessary lines and fittings. It should be installed only after the original G R C M components, including the Control Box, have been properly installed. G a s Deliver 1. Connect the Gas Delivery Manifold Line (Part Number 300794) to Outlet 2 of the GRCM Control Box.
T his chapter describes the application of the Quest Gaseous Reaction and Concentration Manifold when used with the Quest 210 in two processes: Hydrogenation, and Concentration by Evaporation. Hydrogenation requires the Control Box and the Gas Delivery Manifold. Concentration requires the Control Box, the G a s Delivery Manifold and the Solvent Trap Manifold, together with a user-supplied solvent trap.
USING THE G R C M Gaseous Reaction Setup 7 Quest 2 10 Reactor Expansion Kit Gas Delivery Manifold and Line d m n k 8) Gas Delivery Manifold Line' (Part umber 300794) Umbilical Line 3 /Inert \ [ I Gas Inert Gas Extension Line (Part Number 300797) I Quest 210 Controller Port#3456 GRCM Control Box 1 Reagent Gas (e.g.
USING THE G R C M Hydrogenation , Operation T h e following list s h o w s t h e step-by-step procedure f o r carrying out hydrogenation with the setup s h o w n above. 1. Set up the Quest and GRCM as shown in Figure 8. 2. Make sure that the apparatus is clean and free of debris. (See the section "Cleaning the GRCM" below.) 3. Control Box inlets: a. G a s 1 - Nitrogen b. G a s 2 - H2 G a s 4. Add catalyst(s ) to reaction vessels: a. Pre-weigh Pd/C into 10 ml pFritTMreaction vessels. b.
1 1. Purge with nitrogen: a. Slowly turn the Out A needle valve counterclockwise approximately '/4 turn to deliver nitrogen. Caution Excessive opening of the Out A needle valve at this time may cause the liquids in the RV to "bump" (bubble excessively). b. Carefully open the lower manifold drain valves of the Quest reactor to start purging the reaction vessels with nitrogen. 12. Hydrogenation: a.
USING T H E GRCM Concentration By Evaporation ' , 1 1 1 1 1 # 1 1 1 1 1 1 1 1 l 1 1 1 1 1 1 1 1 1 1 1 ~ 1 ~ 1 1 1 1 1 1 1 l 1 1 l t 1 1 1 1 1 1 1 ~ 1 l 1 This section describes an example of a procedure for concentration by evaporation. It is intended solely as an example and should not be interpreted as a definitive or recommended method. S e t u p The figure below shows the setup in schematic form. For details of the installation procedures, see Chapter 3 "GRCM Installation".
Operation The following list shows the step-by-step procedure for carrying out concentration by evaporation with the setup shown above. 1. Set up the Quest and GRCM as shown in Figure 9 2. Connect the Solvent Trap Manifold to a solvent trap. 3. Turn each of the two Quest Control valves to CLOSED. 4. Turn the Gas Selection valve on the GRCM Control Box to Gas 1 (Nitrogen). 5. Slowly turn the Out A needle valve counterclockwise approximately % turn to deliver nitrogen.
USING T H E GRCM a Cleaning the GRCM . Solvent E v a p o r a t i o n R e s u l t s The following table shows the results of an experiment involving the evaporation of several different solvents at one time. The process was carried out over a period of one hour at 45 "C. Up to 80% of the solvent was recovered by the recommended solvent trap. These are representative results. Actual results may vary. a. T h e initial solvent volume was 7 ml. b. The THF was concentrated within 40 minutes.
Using t h e Q u e s t 210 1. Detach the Manifold Delivery Line from the bulkhead fitting on the Quest reactor unit. 2. Detach the Gas Delivery Manifold Line from the proper Out A or Out B outlet on the GRCM control box, and attach it to the Quest 210 at the bulkhead connector. 3. Rest the Gas Delivery Manifold over the Quest waste tray. 4. Start the flow of solvent by turning the Quest 210 Control Valve 1 to SOLVENT for 10-30 seconds. 5.
USING T H E GRCM Cleaning the GRCM 7. Purge the ASW Tray Delivery line: a. On the ASW tray, turn off the solvent switch and turn on the purge switch. b. Turn Control Valve 1 to SOLVENT for 1 minute. c. Turn off the purge switch on the ASW tray. 8. Purge the Gas Delivery Manifold: a. Turn Control Valve 1 to DRAIN GAS for 2 to 5 minutes to remove all solvent from the Gas Delivery Manifold. b. Turn Control Valve 1 to CLOSED. 9.
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CONTACT INFORMATION 1 1 I I t I 1 I 1 I I 1 1 I l I I 1 1 1 I I I I I I I I I I I I I I I I I I I l I I l I I l I I I I I I E-mail: Support@ argotech.com Internet: www.argotech.com I n the U n i t e d S t a t e s : Argonaut Technologies 887 Industrial Road, Suite G San Carlos, CA 94070 USA Phone: 650.598.1350 or 888.598.1350 (USAICanada) Fax: 650.598.1359 In Europe: Argonaut Technologies A.G. St.
In Japan: Argonaut Technologies K.K. MK Kojimachi Bldg. 4-2-1 Kojimachi, Chiyoda-Ku Tokyo 102-0083 Japan Phone: +81-3-3234-432 1 Fax: +81-3-3234-1359 G R C M - U s e r Manual Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.
BASIC GRCM The basic Gas Reaction and Concentration Manifold ( G R C M ) consists of the following components.
EXPANSION KIT l I l l l l I l s l l l t l l I l l I l I I I I I I I I I I I I I I I I I l I I l l l I I I I l I I I l The G R C M Expansion Kit allows you to perform reactions or concentrations on all twenty of the reaction vessels.
Index C I R Cleaning Gas Delivery Manifold 4-26 Overview 4-25 Quest Lower Manifold 4-27 Components 3-9, B-3 1, B-32 Concentration 4- 19.4-23 Operation 4-24 Results 4-25 Setup 4-23 Control Box 1- 1.
INDEX IND E X - 2 G R C M - U s e r Manual Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.
Artisan Technology Group is your source for quality new and certified-used/pre-owned equipment • FAST SHIPPING AND DELIVERY • TENS OF THOUSANDS OF IN-STOCK ITEMS • EQUIPMENT DEMOS • HUNDREDS OF MANUFACTURERS SUPPORTED • LEASING/MONTHLY RENTALS • ITAR CERTIFIED SECURE ASSET SOLUTIONS SERVICE CENTER REPAIRS Experienced engineers and technicians on staff at our full-service, in-house repair center WE BUY USED EQUIPMENT Sell your excess, underutilized, and idle used equipment We also offer credit for buy-back