Specifications

USING THE GRCM
Hydrogenation ,
Operation The following list shows the step-by-step procedure for
carrying out hydrogenation with the setup shown above.
1. Set up the Quest and GRCM as shown in Figure 8.
2. Make sure that the apparatus is clean and free of debris. (See the section
"Cleaning the GRCM" below.)
3. Control Box inlets:
a. Gas 1 - Nitrogen
b. Gas
2 - H2 Gas
4. Add catalyst(s ) to reaction vessels:
a. Pre-weigh Pd/C into 10 ml pFritTM reaction vessels.
b. Insert the reaction vessels into the Quest and drop an agitation magnet into
each one.
5. Purge RVs with nitrogen:
a. Turn the metered gas needle valve clockwise until it is completely closed.
b. Turn Quest control valves to Metered Gas and Utility
1.
c. Slowly turn the metered gas needle valve counterclockwise to purge the
reaction vessels with
N2.
6. Add solvent under nitrogen via syringe:
a. Remove the Upper Manifold luer plugs from the reaction vessels.
b. To each reaction vessel, add the reaction solvent followed by the
hydrogenation substrate in solution.
7. Replace the luer plugs in the Quest Upper Manifold Luer ports, and tighten.
8. Turn the Quest reactor Control Valve 2 from METERED GAS to CLOSED
(leave Control Valve
1 on Utility 1).
9. Connect the H2 tank to inlet port 2 on the GRCM Control Box.
GRCM - User Manual
10. Turn the gas selection valve on the Control Box to Gas 1 (N2).
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