MSDS

Material Safety Data Sheet
MSDS Number: 000000001936
Bayer Advanced Garden All-in-One Rose & Flower Care
Concentrate
MSDS Version 1.1
Page 5 of 8
Assessment Carcinogenicity
Tebuconazole gave no evidence of a carcinogenic potential in an oncogenicity study in rats, however, in a
study using mice there was an increased incidence of hepatocellular neoplasms at a dose level
approximately three-fold greater than the maximum tolerated dose (MTD).
In oncogenicity studies in rats and mice, imidacloprid was not carcinogenic in either species.
ACGIH
None
NTP
None
IARC
None
OSHA
None
Reproductive &
Developmental Toxicity
In a two generation study in rats treated with tebuconazole, smaller litters and
decreased pup body weights were observed in conjunction with maternal toxicity
at the highest concentration tested (1000 ppm).
In a two generation reproduction study in rats, imidacloprid was not a primary
reproductive toxicant. Offspring exhibited re- duced body weights at the high
dose and in conjunction with maternal toxicity.
Tebuconazole produced teratogenic effects in conjunction with maternal toxicity
in mice and rabits via oral and/or dermal exposure. When tested in the rat,
developmental effects were observed in conjunction with maternal toxicity via
oral exposure. Teratogenic effects were not observed in the rat following either
route of exposure.
In developmental toxicity studies in rats and rabbits, there was no evidence of an
embryotoxic or teratogenic potential for imidacloprid. In both species, slight
developmental effects were observed only at high doses and in conjunction with
maternal toxicity.
Neurotoxicity
In an acute oral neurotoxicity screening study in rats, tebuconazole produced
transient neurobehavioral effects without correlating morphological changes in
neural tissues.
In a subchronic dietary neurotoxicity screening study in rats, tebuconazole did
not produce any neurobehavioral symptoms or any microscopic lesions in neural
tissues or skeletal muscle. In a one-generation developmental neurotoxicity
study in rats, dietary concentrations of tebuconazole administered to the dams
during gestation and lactation did not cause any specific neurobehavioral effects
in the offspring. Clinical signs of toxicity, as well as, developmental toxicity were
observed in the offspring, but only in conjunction with maternal toxicity.
In acute and subchronic neurotoxicity screening studies in rats, imidacloprid