STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986 CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY November 23, 2018 The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and republish at least once per year the list of chemicals known to the State to cause cancer or reproductive toxicity.
4-Aminobiphenyl (4-aminodiphenyl) 1-Amino-2,4-dibromoanthraquinone 3-Amino-9-ethylcarbazole hydrochloride 2-Aminofluorene Aminoglutethimide Aminoglycosides 1-Amino-2-methylanthraquinone 2-Amino-5-(5-nitro-2-furyl)-1,3,4thiadiazole 4-Amino-2-nitrophenol Aminopterin Amiodarone hydrochloride Amitraz Amitrole Amoxapine Amsacrine tert-Amyl methyl ether Delisted December 13, 2013 Anabolic steroids Analgesic mixtures containing phenacetin Androstenedione Angiotensin converting enzyme (ACE) inhibitors Aniline Ani
Azathioprine Azathioprine Azobenzene cancer developmental cancer 446-86-6 446-86-6 103-33-3 February 27, 1987 September 1, 1996 January 1, 1990 Barbiturates Beclomethasone dipropionate Benomyl Benthiavalicarb-isopropyl Benz[a]anthracene Benzene Benzene Benzidine [and its salts] Benzidine-based dyes Benzodiazepines Benzo[b]fluoranthene Benzo[j]fluoranthene Benzo[k]fluoranthene Benzofuran Benzophenone Benzo[a]pyrene Benzotrichloride Benzphetamine hydrochloride Benzyl chloride Benzyl violet 4B Beryllium an
2-Bromopropane (2-BP) Bromoxynil Bromoxynil octanoate Butabarbital sodium 1,3-Butadiene 1,3-Butadiene 1,4-Butanediol dimethanesulfonate (Busulfan) 1,4-Butanediol dimethanesulfonate (Busulfan) Butylated hydroxyanisole Butyl benzyl phthalate (BBP) n-Butyl glycidyl ether Delisted April 4, 2014 beta-Butyrolactone Cacodylic acid Cadmium Cadmium and cadmium compounds Caffeic acid Captafol Captan Carbamazepine Carbaryl Carbaryl Carbazole Carbon black (airborne, unbound particles of respirable size) Carbon-black ex
Chlordiazepoxide hydrochloride Chlordimeform Chlorendic acid Chlorinated paraffins (Average chain length, C12; approximately 60 percent chlorine by weight) p-Chloroaniline p-Chloroaniline hydrochloride Chlorodibromomethane Delisted October 29, 1999 Chloroethane (Ethyl chloride) 1-(2-Chloroethyl)-3-cyclohexyl1-nitrosourea (CCNU) (Lomustine) 1-(2-Chloroethyl)-3-cyclohexyl1-nitrosourea (CCNU) Lomustine) 1-(2-Chloroethyl)-3-(4-methylcyclohexyl) -1-nitrosourea (Methyl-CCNU) Chloroform Chloroform Chloromethyl met
Clarithromycin Clobetasol propionate Clofibrate Clomiphene citrate Clomiphene citrate Clorazepate dipotassium CMNP (pyrazachlor) Cobalt metal powder Cobalt [II] oxide Cobalt sulfate Cobalt sulfate heptahydrate Cocaine Coconut oil diethanolamine condensate (cocamide diethanolamine) Codeine phosphate Coke oven emissions Colchicine Conjugated estrogens Conjugated estrogens Creosotes p-Cresidine Cumene Cupferron Cyanazine Cycasin Cycloate Cyclohexanol Delisted January 25, 2002 Cycloheximide Cyclopenta[cd]pyrene
DDE (Dichlorodiphenyldichloroethylene) DDT (Dichlorodiphenyltrichloroethane) o,p’-DDT p,p’-DDT DDVP (Dichlorvos) Demeclocycline hydrochloride (internal use) Des-ethyl atrazine (DEA) Des-isopropyl atrazine (DIA) N,N’-Diacetylbenzidine 2,4-Diaminoanisole 2,4-Diaminoanisole sulfate 2,4-Diamino-6-chloro-s-triazine (DACT) 4,4’-Diaminodiphenyl ether (4,4’-Oxydianiline) 2,4-Diaminotoluene Diaminotoluene (mixed) Delisted November 20, 2015 Diazepam Diazoaminobenzene Diazoxide Dibenz[a,h]acridine Dibenz[a,j]acridine
chloride) Dichlorophene 1,2-Dichloropropane 1,3-Dichloro-2-propanol (1,3-DCP) 1,3-Dichloropropene Dichlorphenamide Diclofop-methyl Diclofop methyl Dicumarol Dieldrin Dienestrol Delisted January 4, 2013 Diepoxybutane Diesel engine exhaust Diethanolamine Di(2-ethylhexyl)phthalate (DEHP) Di(2-ethylhexyl)phthalate (DEHP) 1,2-Diethylhydrazine Diethylstilbestrol (DES) Diethylstilbestrol (DES) Diethyl sulfate Diflunisal Diglycidyl ether Delisted April 4, 2014 Diglycidyl resorcinol ether (DGRE) Di-n-hexyl phthalate
1,2-Dimethylhydrazine 2,6-Dimethyl-N-nitrosomorpholine (DMNM) Dimethyl sulfate N,N-Dimethyl-p-toluidine Dimethylvinylchloride m-Dinitrobenzene o-Dinitrobenzene p-Dinitrobenzene 3,7-Dinitrofluoranthene 3,9-Dinitrofluoranthene 1,3-Dinitropyrene 1,6-Dinitropyrene 1,8-Dinitropyrene Dinitrotoluene (technical grade) 2,4-Dinitrotoluene 2,4-Dinitrotoluene 2,6-Dinitrotoluene 2,6-Dinitrotoluene Dinitrotoluene mixture, 2,4-/2,6Dinocap Dinoseb Di-n-propyl isocinchomeronate (MGK Repellent 326) 1,4-Dioxane Diphenylhydant
Epoxiconazole Ergotamine tartrate Erionite cancer developmental cancer April 15, 2011 April 1, 1990 October 1, 1988 cancer cancer cancer cancer 135319-73-2 379-79-3 12510-42-8/ 66733-21-9 50-28-2 140-67-0 ----- Estradiol 17B Estragole Estrogens, steroidal Estrogen-progestogen (combined) used as menopausal therapy Estrone Estropipate Ethinylestradiol Ethionamide Ethoprop Ethyl acrylate Ethyl alcohol in alcoholic beverages Ethylbenzene Ethyl-tert-butyl ether Delisted December 13, 2013 Ethyl dipropylthioc
Flurbiprofen Flutamide Fluticasone propionate Fluvalinate Folpet Formaldehyde (gas) 2-(2-Formylhydrazino)-4(5-nitro-2-furyl)thiazole Fumonisin B1 Furan Furazolidone Furfuryl alcohol Furmecyclox Fusarin C developmental, female developmental developmental developmental cancer cancer cancer 5104-49-4 13311-84-7 80474-14-2 69409-94-5 133-07-3 50-00-0 3570-75-0 August 20, 1999 July 1, 1990 May 15, 1998 November 6, 1998 January 1, 1989 January 1, 1988 January 1, 1988 cancer cancer cancer cancer cancer cancer
Hexachlorocyclohexane (technical grade) Hexachlorodibenzodioxin Hexachloroethane 2,4-Hexadienal (89% trans, trans isomer; 11% cis, trans isomer) Hexafluoroacetone Hexamethylphosphoramide Hexamethylphosphoramide n-Hexane 2,5-Hexanedione Histrelin acetate Hydramethylnon Hydrazine Hydrazine sulfate Hydrazobenzene (1,2-Diphenylhydrazine) Hydrogen cyanide (HCN) and cyanide salts (CN salts) 1-Hydroxyanthraquinone Hydroxyurea cancer --- October 1, 1987 cancer cancer cancer 34465-46-8 67-72-1 --- April 1, 198
Leuprolide acetate Levodopa Levonorgestrel implants Lindane and other hexachlorocyclohexane isomers Linuron Lithium carbonate Lithium citrate Lorazepam Lovastatin Lynestrenol Malathion Malonaldehyde, sodium salt Mancozeb Maneb Marijuana smoke Me-A-alpha-C (2-Amino-3-methyl9H-pyrido[2,3-b]indole) Mebendazole Medroxyprogesterone acetate Medroxyprogesterone acetate Megestrol acetate Megestrol acetate MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline) MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline) Melpha
fumigant Methyl carbamate Methyl chloride Methyl chloride 3-Methylcholanthrene 5-Methylchrysene 4,4'-Methylene bis(2-chloroaniline) 4,4'-Methylene bis(N,N-dimethyl) benzenamine 4,4'-Methylene bis(2-methylaniline) 4,4'-Methylenedianiline 4,4'-Methylenedianiline dihydrochloride Methyleugenol Methylhydrazine and its salts 2-Methylimidazole 4-Methylimidazole Methyl iodide Methyl isobutyl ketone Methyl isobutyl ketone (MIBK) Methyl isocyanate (MIC) Methyl isopropyl ketone Delisted April 4, 2014 Methyl mercury Me
3-Monochloropropane-1,2diol (3-MCPD) Monocrotaline MOPP (vincristine-prednisonenitrogen mustard-procarbazine mixture) 5-(Morpholinomethyl)-3[(5-nitrofurfuryl-idene)amino]-2-oxazolidinone Mustard Gas MX (3-chloro-4-(dichloromethyl) 5-hydroxy-2(5H)-furanone) Myclobutanil beta-Myrcene cancer 96-24-2 October 8, 2010 cancer cancer 315-22-0 113803-47-7 April 1, 1988 November 4, 2011 cancer 139-91-3 April 1, 1988 cancer cancer 505-60-2 77439-76-0 February 27, 1987 December 22, 2000 developmental, male
Nitrofen (technical grade) 2-Nitrofluorene Nitrofurantoin Nitrofurazone 1-[(5-Nitrofurfurylidene)-amino]2-imidazolidinone N-[4-(5-Nitro-2-furyl)-2-thiazolyl] acetamide Nitrogen mustard (Mechlorethamine) Nitrogen mustard (Mechlorethamine) Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) Nitrogen mustard N-oxide Nitrogen mustard N-oxide hydrochloride Nitromethane 2-Nitropropane 1-Nitropyrene 4-Nitropyrene N-Nitrosodi-n-butylamine N-N
Nitrous oxide Norethisterone (Norethindrone) Norethisterone (Norethindrone) Norethisterone acetate (Norethindrone acetate) Norethisterone (Norethindrone) /Ethinyl estradiol Norethisterone (Norethindrone)/Mestranol Norethynodrel Norgestrel developmental, female cancer developmental developmental 10024-97-2 68-22-4 68-22-4 51-98-9 August 1, 2008 October 1, 1989 April 1, 1990 October 1, 1991 developmental April 1, 1990 cancer developmental 68-22-4/ 57-63-6 68-22-4/ 72-33-3 68-23-5 6533-00-2 Ochratoxin
Phenesterin Phenobarbital Phenolphthalein Phenoxybenzamine Phenoxybenzamine hydrochloride Phenprocoumon o-Phenylenediamine and its salts Phenyl glycidyl ether Phenyl glycidyl ether Delisted April 4, 2014 Phenylhydrazine and its salts o-Phenylphenate, sodium o-Phenylphenol Phenylphosphine PhiP(2-Amino-1-methyl-6phenylimidazol[4,5-b]pyridine) Pimozide Pioglitazone Pipobroman Pirimicarb Plicamycin Polybrominated biphenyls Polybrominated biphenyls Polychlorinated biphenyls Polychlorinated biphenyls Polychlorina
Pyridine Pyrimethamine cancer developmental 110-86-1 58-14-0 May 17, 2002 January 29, 1999 Quazepam Quinoline and its strong acid salts Quizalofop-ethyl developmental cancer male 36735-22-5 --76578-14-8 August 26, 1997 October 24, 1997 December 24, 1999 Radionuclides Reserpine Residual (heavy) fuel oils Resmethrin Resmethrin Retinol/retinyl esters, when in daily dosages in excess of 10,000 IU, or 3,000 retinol equivalents.
Styrene Styrene oxide Sulfallate Sulfasalazine (Salicylazosulfapyridine) Sulfasalazine (Salicylazosulfapyridine) Sulfur dioxide Sulindac cancer cancer cancer cancer 100-42-5 96-09-3 95-06-7 599-79-1 April 22, 2016 October 1, 1988 January 1, 1988 May 15, 1998 male 599-79-1 January 29, 1999 developmental developmental, female 7446-09-5 38194-50-2 July 29, 2011 January 29, 1999 Talc containing asbestiform fibers Tamoxifen and its salts Tamoxifen citrate Temazepam Teniposide Terbacil Teriparatide Terr
Tobramycin sulfate Toluene Toluene diisocyanate o-Toluidine o-Toluidine hydrochloride para-Toluidine Delisted October 29, 1999 Topiramate Toxaphene (Polychlorinated camphenes) Toxins derived from Fusarium Moniliforme (Fusarium verticillioides) Treosulfan Triadimefon Triamterene Triazolam S,S,S-Tributyl phosphorotrithioate (Tribufos, DEF) Tributyltin methacrylate Trichlormethine (Trimustine hydrochloride) Trichloroacetic acid Trichloroethylene Trichloroethylene 2,4,6-Trichlorophenol 1,2,3-Trichloropropane Tr
Unleaded gasoline (wholly vaporized) Uracil mustard cancer --- April 1, 1988 cancer developmental, female, male cancer developmental developmental 66-75-1 April 1, 1988 January 1, 1992 51-79-6 97048-13-0 January 1, 1988 October 1, 1994 April 1, 1990 developmental cancer 99-66-1 1314-62-1 July 1, 1987 February 11, 2005 developmental cancer developmental developmental cancer cancer cancer female, male cancer 143-67-9 50471-44-8 2068-78-2 593-60-2 75-01-4 100-40-3 100-40-3 106-87-6 July 1, 1990 A
