User guide

Search Results- by default the search result appears in the same worksheet on which the search is performed.
The "Display in a new worksheet" option creates a new worksheet with the name "SearchResults X" (where X is
1,2.3...) and displays the search result in this new worksheet, without changing anything in the original worksheet.
Default Style Sheet- specifies the style sheet that is always applied to the structures when structures are added
using "Import Table", "Load Molecule" or by add molecule commands. To apply style to particular molecules, go to
ChemOffice13 >> Molecule >> Style. The default style sheet is "New Document.cds".
CombiChem
Using CombiChem, you can build virtual combinatorial libraries of structurally related molecules. You can then screen
your libraries for various properties to determine which compounds you want to synthesize.
CombiChem is a plugin for Microsoft Excel and is included with ChemDraw/Excel. If you are familiar with Excel, you
will find CombiChem simple to use. However, if you need help, see the Excel User’s Guide.
Getting Started
When you install ChemBioFinder or ChemBioOffice, the CombiChem add-in is also installed. CombiChem requires
Microsoft Excel 2003 or later.
Assistance with Combichem
Combichem provides Help in the Excel worksheets. Go to ChemOffice13>CombiChem>Help.
By default, each worksheet you create also includes brief instructions to help guide you. If you do not see the instruc-
tions:
1. Go to ChemOffice13>CombiChem>Preferences.
2. Select Add Instructions to Every Sheet.
3. Click OK.
The instructions appear on new worksheets that you create.
Creating combinatorial libraries
To create a combinatorial library, you first need a generic reaction. This reaction resembles the real reaction you will
use in the lab to synthesize compounds. The generic reaction contains one or more query structures that represent
the reactants and products in the real reaction. An example of a generic reaction is shown below:
ChemBioDraw 13.0
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