User Manual

Product name: DOWFROST Heat Transfer Fluid
Issue Date: 01/23/2015
Page 7 of 11
Specific Target Organ Systemic Toxicity (Single Exposure)
Evaluation of available data suggests that this material is not an STOT-SE toxicant.
Specific Target Organ Systemic Toxicity (Repeated Exposure)
In rare cases, repeated excessive exposure to propylene glycol may cause central nervous system
effects.
Carcinogenicity
Similar formulations did not cause cancer in laboratory animals.
Teratogenicity
For the major component(s): Did not cause birth defects or any other fetal effects in laboratory
animals.
Reproductive toxicity
For the major component(s): In animal studies, did not interfere with reproduction. In animal studies,
did not interfere with fertility.
Mutagenicity
In vitro genetic toxicity studies were negative. For the major component(s): Animal genetic toxicity
studies were negative.
Aspiration Hazard
Based on physical properties, not likely to be an aspiration hazard.
12. ECOLOGICAL INFORMATION
Ecotoxicological information on this product or its components appear in this section when such data
is available.
Toxicity
Propylene glycol
Acute toxicity to fish
Material is practically non-toxic to aquatic organisms on an acute basis
(LC50/EC50/EL50/LL50 >100 mg/L in the most sensitive species tested).
LC50, Oncorhynchus mykiss (rainbow trout), static test, 96 Hour, 40,613 mg/l, OECD Test
Guideline 203
Acute toxicity to aquatic invertebrates
LC50, Ceriodaphnia dubia (water flea), static test, 48 Hour, 18,340 mg/l, OECD Test Guideline
202
Acute toxicity to algae/aquatic plants
ErC50, Pseudokirchneriella subcapitata (green algae), 96 Hour, Growth rate inhibition, 19,000
mg/l, OECD Test Guideline 201
Toxicity to bacteria
NOEC, Pseudomonas putida, 18 Hour, > 20,000 mg/l
Chronic toxicity to aquatic invertebrates