SDS

CEF00022
Du Pont
Material Safety Data Sheet
Page 6
Printed on 03/09/2011
TOXICOLOGICAL INFORMATION
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Animal Data
INHALATION:
4 hour, LC50, rat: 220,000 ppm.
Inhalation 4 hour, LC50, rat: 220,000 ppm
Single inhalation exposure to high doses caused central
nervous depression, inactivity or anaesthesia, altered
respiratory rate, and cardiac sensitization (a potentially
fatal disturbance of heart rhythm associated with a
heightened sensitivity to the action of epinephrine).
No data are available on acute oral or dermal toxicity for
this substance.
Animal testing indicates this substance is not an eye
irritant.
Animal testing indicates this substance is not a skin
irritant or skin sensitizer.
Repeated inhalation exposure caused reduced body weight gain
and organ weight effects. In chronic inhalation studies, an
increased incidence of tumors was observed in some
laboratory animals but not in others. The overall weight of
evidence indicates that the substance is not carcinogenic.
Animal testing showed effects on embryo-fetal development at
exposure levels equal to or above those causing maternal
toxicity. This substance is not considered a unique
developmental hazard to the conceptus. Evidence suggests
the substance is not a reproductive toxin in animals.
Experiments showed the substance to cause mutagenic effects
in cultured bacterial cells. The substance did not cause
genetic damage in cultured mammalian cells. Evidence
suggests this substance does not cause genetic damage in
animals.
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ECOLOGICAL INFORMATION
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Ecotoxicological Information
Aquatic Toxicity:
"FREON" 22
48 hour EC50 - Daphnia magna: 433 mg/L
96 hour LC50, Zebra fish: 777 mg/L