HP LeftHand SAN Solutions Support Document - Application Notes - Virtualization SAN - Performance

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Dedicate a separate IP subnet/VLAN for your iSCSI SAN.
Use a secondary Gigabit Ethernet NIC in servers attached to the
Ethernet storage subnet for high availability and performance.
If possible attach all modules and application servers to the same
Gigabit switches for the storage networking.
Make sure all switch ports and Ethernet adapters are configured to
run at Full-duplex Gigabit speeds.
Disk Formatting Best Practices
Use the default block size, or allocation unit size, unless a particular
application specifies an alternate size. Microsoft Exchange should be
on volumes formatted with a block size of 4096 bytes.
Partitions should be created starting at sector 128 to align the offset to
64KB using Diskpar or Diskpart.
Storage Node Configuration Best Practices
Bond networks interfaces for network redundancy and more
bandwidth using Adaptive Load Balancing (ALB).
Use RAID level 5 or 10 for disk redundancy within storage modules.
Enable SAN/iQ iSCSI Load Balancing on authentication groups for
Windows servers
Install the DSM software driver to enable fault-tolerant paths to the
SAN modules while also increasing available bandwidth to the SAN
for maximum performance
Performance Test Environment for Realistic Application Benchmarks
Performance data was gathered using enterprise class servers with the
following attributes:
2.8GHz dual core Intel Xeon processor
4 gigabytes of RAM
Dual gigabit Ethernet network adapters (bonded using balance ALB)
All equipment connected to the same gigabit Ethernet switch