SDS
Version No: 4.9
Page 6 of 10
ClearWeld Hardener, Part B
Issue Date: 03/20/2023
Print Date: 06/07/2023
Continued...
ClearWeld Hardener, Part B
pentaerythritol, propoxylated,
mercaptoglycerol capped
benzyl alcohol
trimethylhexamethylene
diamine
triethylenetetramine
N-aminoethylpiperazine
trimethylolpropane triamine
ether, propoxylated
bis(2-
dimethylaminoethyl)ether
Legend:
1. Value obtained from Europe ECHA Registered Substances - Acute toxicity 2. Value obtained from manufacturer's SDS. Unless otherwise
specified data extracted from RTECS - Register of Toxic Effect of chemical Substances
pentaerythritol, propoxylated,
mercaptoglycerol capped
Polyethers (such as ethoxylated surfactants and polyethylene glycols) are highly susceptible to being oxidized in the air. They then form complex
mixtures of oxidation products.
Animal testing reveals that whole the pure, non-oxidised surfactant is non-sensitizing, many of the oxidation products are sensitisers. Both the
vitro skin corrosion test and the vivo skin irritation study did not show significant irritating properties A reliable in vivo eye irritation in rabbit is
available, demonstrating no significant eye irritating properties. In a LLNA study it was shown that the material could elicit a SI =3. Based on this
result, the material needs to be classified as a skin sensitiser, according to Regulation (EC) No 1272/2008 on Classification, Labelling and
Packaging of Substances and Mixtures. A 90-day oral gavage study in rats was performed according to GLP and OECD 408 (1998). Based on
decreased platelet count and increased incidence of follicular hypertrophy/hyperplasia in the thyroid glands in males at 250 mg/kg bw/d and
above, the NOAEL was set at 75 mg/kg bw/d. Based on the available data on genetic toxicity, the substance needs not to be classified for
genotoxicity according to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of Substances and Mixture * REACh
Dossier
benzyl alcohol
Unlike benzylic alcohols, the beta-hydroxyl group of the members of benzyl alkyl alcohols contributes to break down reactions but do not undergo
phase II metabolic activation. Though structurally similar to cancer causing ethyl benzene, phenethyl alcohol is only of negligible concern due to
limited similarity in their pattern of activity.
For benzoates:
Benzyl alcohol, benzoic acid and its sodium and potassium salt have a common metabolic and excretion pathway. All but benzyl alcohol are
considered to be unharmful and of low acute toxicity.
Adverse reactions to fragrances in perfumes and fragranced cosmetic products include allergic contact dermatitis, irritant contact dermatitis,
sensitivity to light, immediate contact reactions, and pigmented contact dermatitis. Airborne and connubial contact dermatitis occurs.
Fragrance allergens act as haptens, low molecular weight chemicals that cause an immune response only when attached to a carrier protein.
However, not all sensitizing fragrance chemicals are directly reactive, but require previous activation.
The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of
vesicles, scaling and thickening of the skin.
This is a member or analogue of a group of benzyl derivatives generally regarded as safe (GRAS), based partly on their self-limiting properties as
flavouring substances in food. In humans and other animals, they are rapidly absorbed, broken down and excreted, with a wide safety margin.
The aryl alkyl alcohol (AAA) fragrance ingredients have diverse chemical structures, with similar metabolic and toxicity profiles. The AAA
fragrances demonstrate low acute and subchronic toxicity by skin contact and swallowing.
TOXICITY
IRRITATION
Not Available
Not Available
TOXICITY
IRRITATION
Dermal (rabbit) LD50: >10200 mg/kg *
[2]
Not Available
Inhalation(Rat) LC50: >100 mg/m3 *
[2]
Oral (Rat) LD50: 2600 mg/kg *
[2]
TOXICITY
IRRITATION
Dermal (rabbit) LD50: 2000 mg/kg
[2]
Eye (rabbit): 0.75 mg open SEVERE
Inhalation (Rat)LC50: >4178 mg/m3/4h
[2]
Eye: adverse effect observed (irritating)
[1]
Inhalation (Rat)LC50: 1000 ppm/8h
[2]
Skin (man): 16 mg/48h-mild
Inhalation (Rat)LCLo: 2000 ppm/4h
[2]
Skin (rabbit):10 mg/24h open-mild
Oral (Rat) LD50: 1230 mg/kg
[2]
Skin: no adverse effect observed (not irritating)
[1]
TOXICITY
IRRITATION
Oral (Rat) LD50: 910 mg/kg
[2]
Not Available
TOXICITY
IRRITATION
Dermal (rabbit) LD50: 805 mg/kg
[2]
Not Available
Oral (Rat) LD50: 2500 mg/kg
[2]
TOXICITY
IRRITATION
Dermal (rabbit) LD50: 880 mg/kg
[2]
Eye (rabbit): 20 mg/24h - mod
Intraperitoneal (Mouse) LD50: 250 mg/kg
[2]
Eye: adverse effect observed (irritating)
[1]
Oral (Rat) LD50: 2410 mg/kg
[2]
Skin (rabbit): 0.1 mg/24h - mild
Skin (rabbit): 5 mg/24h - SEVERE
Skin: adverse effect observed (corrosive)
[1]
TOXICITY
IRRITATION
Dermal (rabbit) LD50: 561.6 mg/kg
[1]
Eye: adverse effect observed (irreversible damage)
[1]
Oral (Rat) LD50: 50-200 mg/kg
[1]
Skin: adverse effect observed (irritating)
[1]
TOXICITY
IRRITATION
Dermal (rabbit) LD50: 238 mg/kg
[2]
Not Available
Inhalation(Rat) LC50: >2.204 mg/l4h
[1]
Oral (Rat) LD50: 571 mg/kg
[2]