SDS

Possibility of hazardous
reactions
See section 7
Conditions to avoid
See section 7
Incompatible materials
See section 7
Hazardous decomposition
products
See section 5
SECTION 11 Toxicological information
Information on toxicological effects
Inhaled
The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified by EC Directives using animal
models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an
occupational setting.
Ingestion
The material has
NOT
been classified by EC Directives or other classification systems as "harmful by ingestion". This is because of the lack of
corroborating animal or human evidence.
Skin Contact
Skin contact is not thought to have harmful health effects (as classified under EC Directives); the material may still produce health damage
following entry through wounds, lesions or abrasions.
There is some evidence to suggest that this material can cause inflammation of the skin on contact in some persons.
Open cuts, abraded or irritated skin should not be exposed to this material
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin
prior to the use of the material and ensure that any external damage is suitably protected.
Eye
Although the material is not thought to be an irritant (as classified by EC Directives), direct contact with the eye may produce transient discomfort
characterised by tearing or conjunctival redness (as with windburn).
Chronic
Ample evidence from experiments exists that there is a suspicion this material directly reduces fertility.
Amorphous silicas generally are less hazardous than crystalline silicas, but the former can be converted to the latter on heating and subsequent
cooling. Inhalation of dusts containing crystalline silicas may lead to silicosis, a disabling lung disease that may take years to develop.
Soluble silicates do not exhibit sensitizing potential. Testing in bacterial and animal experiments have not shown any evidence of them causing
mutations or birth defects.
There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment.
PlasticBonder™ Syringe Tan -
Part B
TOXICITY
IRRITATION
Not Available
Not Available
Talc
TOXICITY
IRRITATION
dermal (rat) LD50: >2000 mg/kg
[1]
Eye: no adverse effect observed (not irritating)
[1]
Inhalation(Rat) LC50: >2.1 mg/l4h
[1]
Skin: no adverse effect observed (not irritating)
[1]
Oral (Rat) LD50: >5000 mg/kg
[1]
piperazine
TOXICITY
IRRITATION
Dermal (rabbit) LD50: 4000 mg/kg
[2]
Eye (rabbit): 0.25 mg/24h SEVERE Nil reported
Oral (Rat) LD50: 1900 mg/kg
[2]
Eye (rabbit): 0.75 mg SEVERE
Skin (rabbit): 500 mg open mild
silica amorphous
TOXICITY
IRRITATION
dermal (rat) LD50: >2000 mg/kg
[1]
Eye (rabbit): non-irritating ** [Grace]
Inhalation(Rat) LC50: >0.09<0.84 mg/l4h
[1]
Eye: no adverse effect observed (not irritating)
[1]
Oral (Rat) LD50: >1000 mg/kg
[1]
Skin (rabbit): non-irritating *
Skin: no adverse effect observed (not irritating)
[1]
IsHiddenTemplateTag=true
1. Value obtained from Europe ECHA Registered Substances - Acute toxicity 2. Value obtained from manufacturer's SDS. Unless otherwise
specified data extracted from RTECS - Register of Toxic Effect of chemical Substances
PIPERAZINE
for hexahydrate [RTECS No.: TM 0850000]
The following information refers to contact allergens as a group and may not be specific to this product.
Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's oedema. The pathogenesis of contact
eczema involves a cell-mediated (T lymphocytes) immune reaction of the delayed type.
Allergic reactions involving the respiratory tract are usually due to interactions between IgE antibodies and allergens and occur rapidly. Allergic
potential of the allergen and period of exposure often determine the severity of symptoms. Some people may be genetically more prone than
others, and exposure to other irritants may aggravate symptoms.
Attention should be paid to atopic diathesis, characterised by increased susceptibility to nasal inflammation, asthma and eczema.
Exogenous allergic alveolitis is induced essentially by allergen specific immune-complexes of the IgG type; cell-mediated reactions (T
lymphocytes) may be involved. Such allergy is of the delayed type with onset up to four hours following exposure.
for piperazine:
Exposure to piperazine and its salts has clearly been demonstrated to cause asthma in occupational settings. No NOAEL can be estimated for
respiratory sensitisation (asthma).
Although the LD50 levels indicate a relatively low level of oral acute toxicity (LD50 1-5 g/kg bw), signs of neurotoxicity may appear in humans
after exposure to lower doses. Based on exposure levels of up to 3.4 mg/kg/day piperazine base and a LOAEL of 110 mg/kg, there is no concern
for acute toxicity
In pigs, piperazine is readily absorbed from the gastrointestinal tract, and the major part of the resorbed compound is excreted as unchanged
piperazine during the first 48 hours.
Ethyleneamines are very reactive and can cause chemical burns, skin rashes and asthma-like symptoms. It is readily absorbed through the skin
and may cause eye blindness and irreparable damage. As such, they require careful handling.
Version No:
7.14
Page
7
of
10
PlasticBonder™ Syringe Tan - Part B
Issue Date:
10/25/2023
Print Date:
02/07/2024
Continued...