SDS
IsHiddenTemplateTag=true
– Data either not available or does not fill the criteria for classification
– Data available to make classification
The material may be irritating to the eye, with prolonged contact causing inflammation. Repeated or prolonged exposure to irritants may produce
conjunctivitis.
Asthma-like symptoms may continue for months or even years after exposure to the material ends. This may be due to a non-allergic condition
known as reactive airways dysfunction syndrome (RADS) which can occur after exposure to high levels of highly irritating compound. Main
criteria for diagnosing RADS include the absence of previous airways disease in a non-atopic individual, with sudden onset of persistent
asthma-like symptoms within minutes to hours of a documented exposure to the irritant.
The material may produce respiratory tract irritation, and result in damage to the lung including reduced lung function.
The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of
vesicles, scaling and thickening of the skin.
NOTE:
Substance has been shown to be mutagenic in at least one assay, or belongs to a family of chemicals producing damage or change to
cellular DNA.
SILICA AMORPHOUS
Reports indicate high/prolonged exposures to amorphous silicas induced lung fibrosis in experimental animals; in some experiments these
effects were reversible. [PATTYS]
The substance is classified by IARC as Group 3:
NOT
classifiable as to its carcinogenicity to humans.
Evidence of carcinogenicity may be inadequate or limited in animal testing.
PlasticBonder™ Syringe Tan -
Part B & SILICA AMORPHOUS
For silica amorphous:
Derived No Adverse Effects Level (NOAEL) in the range of 1000 mg/kg/d.
In humans, synthetic amorphous silica (SAS) is essentially non-toxic by mouth, skin or eyes, and by inhalation. Epidemiology studies show little
evidence of adverse health effects due to SAS. Repeated exposure (without personal protection) may cause mechanical irritation of the eye and
drying/cracking of the skin.
When experimental animals inhale synthetic amorphous silica (SAS) dust, it dissolves in the lung fluid and is rapidly eliminated.
Acute Toxicity
Carcinogenicity
Skin Irritation/Corrosion
Reproductivity
Serious Eye Damage/Irritation
STOT - Single Exposure
Respiratory or Skin
sensitisation
STOT - Repeated Exposure
Mutagenicity
Aspiration Hazard
SECTION 12 Ecological information
Toxicity
PlasticBonder™ Syringe Tan -
Part B
Endpoint
Test Duration (hr)
Species
Value
Source
Not
Available
Not Available
Not Available
Not
Available
Not
Available
Talc
Endpoint
Test Duration (hr)
Species
Value
Source
EC50
96h
Algae or other aquatic plants
7202.7mg/l
2
LC50
96h
Fish
89581.016mg/l
2
NOEC(ECx)
720h
Algae or other aquatic plants
918.089mg/l
2
piperazine
Endpoint
Test Duration (hr)
Species
Value
Source
BCF
1008h
Fish
<0.3-0.9
7
EC50
72h
Algae or other aquatic plants
153.1mg/l
2
EC50
48h
Crustacea
21mg/l
2
LC50
96h
Fish
>100mg/l
2
NOEC(ECx)
Not Available
Fish
>1mg/l
2
silica amorphous
Endpoint
Test Duration (hr)
Species
Value
Source
EC50
72h
Algae or other aquatic plants
14.1mg/l
2
EC50
48h
Crustacea
>86mg/l
2
EC50
96h
Algae or other aquatic plants
217.576mg/l
2
LC50
96h
Fish
1033.016mg/l
2
EC0(ECx)
24h
Crustacea
>=10000mg/l
1
IsHiddenTemplateTag=true
Extracted from 1. IUCLID Toxicity Data 2. Europe ECHA Registered Substances - Ecotoxicological Information - Aquatic Toxicity 4. US EPA,
Ecotox database - Aquatic Toxicity Data 5. ECETOC Aquatic Hazard Assessment Data 6. NITE (Japan) - Bioconcentration Data 7. METI (Japan)
- Bioconcentration Data 8. Vendor Data
Microbial methylation plays important roles in the biogeochemical cycling of the metalloids and possibly in their detoxification. Many microorganisms (bacteria, fungi, and yeasts) and
animals are now known to biomethylate arsenic, forming both volatile (e.g., methylarsines) and nonvolatile (e.g., methylarsonic acid and dimethylarsinic acid) compounds. Antimony
and bismuth, also undergo biomethylation to some extent.
For Amorphous Silica: Amorphous silica is chemically and biologically inert. It is not biodegradable.
Aquatic Fate: Due to its insolubility in water there is a separation at every filtration and sedimentation process.
For Silica:
Environmental Fate: Most documentation on the fate of silica in the environment concerns dissolved silica, in the aquatic environment, regardless of origin, (man-made or natural), or
structure, (crystalline or amorphous).
Terrestrial Fate: Silicon makes up 25.7% of the Earth's crust, by weight, and is the second most abundant element, being exceeded only by oxygen. Silicon is not found free in nature,
but occurs chiefly as the oxide and as silicates.
DO NOT
discharge into sewer or waterways.
Version No:
7.14
Page
8
of
10
PlasticBonder™ Syringe Tan - Part B
Issue Date:
10/25/2023
Print Date:
02/07/2024
Continued...