SDS

Incompatible materials
See section 7
Hazardous decomposition
products
See section 5
SECTION 11 Toxicological information
Information on toxicological effects
Inhaled
The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.
There is strong evidence to suggest that this material can cause, if inhaled once, serious, irreversible damage of organs.
The vapour/mist may be highly irritating to the upper respiratory tract and lungs; the response may be severe enough to produce bronchitis and
pulmonary oedema. Possible neurological symptoms arising from isocyanate exposure include headache, insomnia, euphoria, ataxia, anxiety
neurosis, depression and paranoia. Gastrointestinal disturbances are characterised by nausea and vomiting.
Inhalation of aerosols (mists, fumes), generated by the material during the course of normal handling, may be harmful.
Ingestion
Strong evidence exists that exposure to the material may cause irreversible damage (other than cancer, mutations and birth defects) following a
single exposure by swallowing.
The material has
NOT
been classified by EC Directives or other classification systems as 'harmful by ingestion'. This is because of the lack of
corroborating animal or human evidence.
Accidental ingestion of the material may be seriously damaging to the health of the individual; animal experiments indicate that ingestion of less
than 40 gram may be fatal.
Skin Contact
This material can cause inflammation of the skin on contact in some persons.
There is strong evidence to suggest that this material, on a single contact with skin, can cause serious, irreversible damage of organs.
The material may accentuate any pre-existing dermatitis condition
Skin contact with the material may damage the health of the individual; systemic effects may result following absorption.
Open cuts, abraded or irritated skin should not be exposed to this material
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin
prior to the use of the material and ensure that any external damage is suitably protected.
Eye
This material may produce eye irritation in some persons and produce eye damage 24 hours or more after instillation. Moderate inflammation
may be expected with redness; conjunctivitis may occur with prolonged exposure.
Chronic
There has been concern that this material can cause cancer or mutations, but there is not enough data to make an assessment.
Repeated or long-term occupational exposure is likely to produce cumulative health effects involving organs or biochemical systems.
Long-term exposure to respiratory irritants may result in airways disease, involving difficulty breathing and related whole-body problems.
Inhaling this product is more likely to cause a sensitisation reaction in some persons compared to the general population.
Skin contact with the material is more likely to cause a sensitisation reaction in some persons compared to the general population.
This product contains a polymer with a functional group considered to be of high concern. Isothiocyanates may cause hypersensitivity of the skin
and airways.
Fully reacted polyurethane polymer is chemically inert. No exposure limits have been established in the U.S. by OSHA (Occupational Safety and
Health Administration) or ACGIH (American Conference of Governmental Industrial Hygienists). It is not regulated by OSHA for carcinogenicity.
Amorphous silicas generally are less hazardous than crystalline silicas, but the former can be converted to the latter on heating and subsequent
cooling. Inhalation of dusts containing crystalline silicas may lead to silicosis, a disabling lung disease that may take years to develop.
Soluble silicates do not exhibit sensitizing potential. Testing in bacterial and animal experiments have not shown any evidence of them causing
mutations or birth defects.
Persons with a history of asthma or other respiratory problems or are known to be sensitised, should not be engaged in any work involving the
handling of isocyanates.
The chemistry of reaction of isocyanates, as evidenced by MDI, in biological milieu is such that in the event of a true exposure of small MDI
doses to the mouth, reactions will commence at once with biological macromolecules in the buccal region and will continue along the digestive
tract prior to reaching the stomach. Reaction products will be a variety of polyureas and macromolecular conjugates with for example mucus,
proteins and cell components.
Animal testing shows that polymeric MDI can damage the nasal cavities and lungs, causing inflammation.and increased cell growth.
PlasticBonder™ Syringe
Black - Part A
TOXICITY
IRRITATION
Not Available
Not Available
4,4'-diphenylmethane
diisocyanate (MDI)
TOXICITY
IRRITATION
Dermal (rabbit) LD50: >6200
mg/kg
[2]
Eye: no adverse effect observed (not irritating)
[1]
Inhalation(Rat) LC50: 0.368
mg/L4h
[1]
Skin (rabbit): 500 mg /24 hours Dermal Sensitiser *Respiratory Sensitiser (g.pig) *[* = Bayer CCINFO
2133615]
Oral (Mouse) LD50; 2200 mg/kg
[2]
Skin: adverse effect observed (irritating)
[1]
MDI, propoxylated
TOXICITY
IRRITATION
Not Available
Not Available
MDI homopolymer
TOXICITY
IRRITATION
Oral (Rat) LD50: >5000 mg/kg
[1]
Eye: no adverse effect observed (not irritating)
[1]
Skin: adverse effect observed (irritating)
[1]
zeolites
TOXICITY
IRRITATION
Version No:
11.16
Page
11
of
16
PlasticBonder™ Syringe Black - Part A
Issue Date:
12/07/2023
Print Date:
12/07/2023
Continued...