SDS

Dermal (rabbit) LD50: >2000 mg/kg
[2]
Not Available
Inhalation(Rat) LC50: >0.5 mg/l4h
[2]
Oral (Rat) LD50: >2000 mg/kg
[1]
Talc
TOXICITY
IRRITATION
dermal (rat) LD50: >2000 mg/kg
[1]
Eye: no adverse effect observed (not irritating)
[1]
Inhalation(Rat) LC50: >2.1 mg/l4h
[1]
Skin: no adverse effect observed (not irritating)
[1]
Oral (Rat) LD50: >5000 mg/kg
[1]
MDI, propylene glycol,
trimethylolpropane,triether
TOXICITY
IRRITATION
Not Available
Not Available
silica amorphous
TOXICITY
IRRITATION
dermal (rat) LD50: >2000 mg/kg
[1]
Eye (rabbit): non-irritating ** [Grace]
Inhalation(Rat) LC50: >0.09<0.84 mg/l4h
[1]
Eye: no adverse effect observed (not irritating)
[1]
Oral (Rat) LD50: >1000 mg/kg
[1]
Skin (rabbit): non-irritating *
Skin: no adverse effect observed (not irritating)
[1]
propylene carbonate
TOXICITY
IRRITATION
Dermal (rabbit) LD50: >=2000 mg/kg
[1]
Eye (rabbit): 60 mg - moderate
Oral (Rat) LD50: >5000 mg/kg
[1]
Eye: adverse effect observed (irritating)
[1]
Skin (human): 100 mg/3d-I moderate
Skin (rabbit): 500 mg moderate
Skin: no adverse effect observed (not irritating)
[1]
Legend:
1. Value obtained from Europe ECHA Registered Substances - Acute toxicity 2. Value obtained from manufacturer's SDS. Unless otherwise
specified data extracted from RTECS - Register of Toxic Effect of chemical Substances
4,4'-DIPHENYLMETHANE
DIISOCYANATE (MDI)
Inhalation (human) TCLo: 0.13 ppm/30 mins Eye (rabbit): 0.10 mg moderate
Aromatic and aliphatic diisocyanates may cause airway toxicity and skin sensitization. Monomers and prepolymers exhibit similar
respiratory effect. Of the several members of diisocyanates tested on experimental animals by inhalation and oral exposure, some caused
cancer while others produced a harmless outcome.
MDI HOMOPOLYMER
as polymethylene polyphenyl isocyanate
ZEOLITES
Inhalation (-) LC50: >18.3 mg/l/1hr for sodium aluminosilicate, zeolite A: Skin (rabbit): non-irritating Eye (rabbit): slight [Grace]
SILICA AMORPHOUS
Reports indicate high/prolonged exposures to amorphous silicas induced lung fibrosis in experimental animals; in some experiments these
effects were reversible. [PATTYS]
PROPYLENE CARBONATE
WARNING:
This substance has been classified by the IARC as Group 2B: Possibly Carcinogenic to Humans.
The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the
production of vesicles, scaling and thickening of the skin.
for propylene carbonate:
Numerous adequate and reliable acute toxicity tests are available on propylene carbonate. Oral and dermal tests meet OECD and EPA test
guidelines. Propylene carbonate is practically nontoxic following acute exposures; the oral LD50 is >.5000 mg/kg and the dermal LD50 is
>3000 mg/kg.
PlasticBonder™ Syringe Black -
Part A & 4,4'-DIPHENYLMETHANE
DIISOCYANATE (MDI) & MDI,
PROPOXYLATED & MDI
HOMOPOLYMER & MDI,
PROPYLENE GLYCOL,
TRIMETHYLOLPROPANE,TRIETHER
Asthma-like symptoms may continue for months or even years after exposure to the material ends. This may be due to a non-allergic
condition known as reactive airways dysfunction syndrome (RADS) which can occur after exposure to high levels of highly irritating
compound. Main criteria for diagnosing RADS include the absence of previous airways disease in a non-atopic individual, with sudden
onset of persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant.
Allergic reactions involving the respiratory tract are usually due to interactions between IgE antibodies and allergens and occur rapidly.
Allergic potential of the allergen and period of exposure often determine the severity of symptoms. Some people may be genetically more
prone than others, and exposure to other irritants may aggravate symptoms.
Attention should be paid to atopic diathesis, characterised by increased susceptibility to nasal inflammation, asthma and eczema.
Exogenous allergic alveolitis is induced essentially by allergen specific immune-complexes of the IgG type; cell-mediated reactions (T
lymphocytes) may be involved. Such allergy is of the delayed type with onset up to four hours following exposure.
The following information refers to contact allergens as a group and may not be specific to this product.
Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's oedema. The pathogenesis of
contact eczema involves a cell-mediated (T lymphocytes) immune reaction of the delayed type.
PlasticBonder™ Syringe Black -
Part A & SILICA AMORPHOUS
For silica amorphous:
Derived No Adverse Effects Level (NOAEL) in the range of 1000 mg/kg/d.
In humans, synthetic amorphous silica (SAS) is essentially non-toxic by mouth, skin or eyes, and by inhalation. Epidemiology studies show
little evidence of adverse health effects due to SAS. Repeated exposure (without personal protection) may cause mechanical irritation of
the eye and drying/cracking of the skin.
When experimental animals inhale synthetic amorphous silica (SAS) dust, it dissolves in the lung fluid and is rapidly eliminated.
PlasticBonder™ Syringe Black -
Part A & 4,4'-DIPHENYLMETHANE
DIISOCYANATE (MDI) & MDI,
PROPOXYLATED & MDI
Isocyanate vapours are irritating to the airways and can cause their inflammation, with wheezing, gasping, severe distress, even loss of
consciousness and fluid in the lungs. Nervous system symptoms that may occur include headache, sleep disturbance, euphoria,
inco-ordination, anxiety, depression and paranoia.
Version No:
11.16
Page
12
of
16
PlasticBonder™ Syringe Black - Part A
Issue Date:
12/07/2023
Print Date:
12/07/2023
Continued...