Safety data sheet

Safety data sheet according to Regulation (EC) No 1907/2006, Annex II
Revision date / version: 21.08.2015 / 0011
Replacing version dated / version: 10.06.2015 / 0010
Valid from: 21.08.2015
PDF print date: 27.08.2015
Liquimate 7700 mini Rapid 25 mL
Art.: 6126 (B)
Acute toxicity, by dermal route: LD50 4250 mg/kg Rabbit OECD 402 (Acute
Dermal Toxicity)
Acute toxicity, by inhalation: LC50 5,3 mg/l Rat OECD 403 (Acute
Inhalation Toxicity)
Skin corrosion/irritation: Rabbit OECD 404 (Acute
Dermal
Irritation/Corrosion)
Not irritant
Serious eye damage/irritation: Rabbit OECD 405 (Acute Eye
Irritation/Corrosion)
Irritant
Respiratory or skin sensitisation: Guinea pig OECD 406 (Skin
Sensitisation)
Negative
Carcinogenicity: Negative
Reproductive toxicity: NOAEL 1500 mg/kg/d
Aspiration hazard: No
Symptoms: acidosis, drop in blood
pressure, vomiting,
headaches, cramps,
dizziness, visual
disturbances, nausea
Specific target organ toxicity -
repeated exposure (STOT-RE),
oral:
NOAEL 500 mg/kg Rat OECD 407 (Repeated
Dose 28-Day Oral
Toxicity Study in
Rodents)
Specific target organ toxicity -
repeated exposure (STOT-RE),
inhalat.:
NOAEL 0,225 mg/kg Rat OECD 412 (Subacute
Inhalation Toxicity - 28-
Day Study)
2,2'-methylenediphenyl diisocyanate
Toxicity / effect Endpoin
t
Value Unit Organism Test method Notes
Acute toxicity, by oral route: LD50 >2000 mg/kg Rat Regulation (EC)
440/2008 B.1 (ACUTE
ORAL TOXICITY)
Analogous conclusion
Acute toxicity, by dermal route: LD50 >9400 mg/kg Rabbit OECD 402 (Acute
Dermal Toxicity)
Analogous conclusion
Skin corrosion/irritation: Rabbit OECD 404 (Acute
Dermal
Irritation/Corrosion)
Irritant
Serious eye damage/irritation: Rabbit OECD 405 (Acute Eye
Irritation/Corrosion)
Irritant, Analogous
conclusion
Respiratory or skin sensitisation: Mouse OECD 429 (Skin
Sensitisation - Local
Lymph Node Assay)
Yes (skin contact)
Respiratory or skin sensitisation: Guinea pig Yes (inhalation),
Analogous conclusion
Germ cell mutagenicity: Salmonella
typhimurium
OECD 471 (Bacterial
Reverse Mutation Test)
Negative, Analogous
conclusion
Carcinogenicity: Rat OECD 453 (Combined
Chronic
Toxicity/Carcinogenicity
Studies)
Limited evidence of a
carcinogenic effect.,
Analogous conclusion,
Aerosol
Reproductive toxicity: NOAEL 4 mg/m3 Rat OECD 414 (Prenatal
Developmental
Toxicity Study)
No indications of such an
effect., Aerosol,
Analogous conclusion
Specific target organ toxicity -
repeated exposure (STOT-RE):
NOAEL 0,2 Rat OECD 453 (Combined
Chronic
Toxicity/Carcinogenicity
Studies)
Aerosol, Analogous
conclusion
Specific target organ toxicity -
repeated exposure (STOT-RE):
LOAEL 1 Rat OECD 453 (Combined
Chronic
Toxicity/Carcinogenicity
Studies)
Aerosol, Analogous
conclusion
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