Certifications 2

SDS No.: 164824 V007.0
LOCTITE SI 5368 BK CR310ML EGF
Page 11 of 17
Germ cell mutagenicity:
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result
Type of study /
Route of
administration
Metabolic
activation /
Exposure time
Species
Method
octamethylcyclotetrasilox
ane
556-67-2
negative
bacterial gene
mutation assay
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
octamethylcyclotetrasilox
ane
556-67-2
negative
in vitro mammalian
chromosome
aberration test
with and without
equivalent or similar to OECD
Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
octamethylcyclotetrasilox
ane
556-67-2
negative
mammalian cell
gene mutation assay
with and without
equivalent or similar to OECD
Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Methyltriacetoxysilane
4253-34-3
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Methyltriacetoxysilane
4253-34-3
negative
in vitro mammalian
chromosome
aberration test
with and without
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
Methyltriacetoxysilane
4253-34-3
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Decamethylcyclopentasilo
xane
541-02-6
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Decamethylcyclopentasilo
xane
541-02-6
negative
in vitro mammalian
chromosome
aberration test
with and without
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
Decamethylcyclopentasilo
xane
541-02-6
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Dodecamethylcyclohexasi
loxane
540-97-6
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Dodecamethylcyclohexasi
loxane
540-97-6
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
octamethylcyclotetrasilox
ane
556-67-2
negative
inhalation
rat
equivalent or similar to OECD
Guideline 475 (Mammalian
Bone Marrow Chromosome
Aberration Test)
octamethylcyclotetrasilox
ane
556-67-2
negative
oral: gavage
rat
equivalent or similar to OECD
Guideline 478 (Genetic
Toxicology: Rodent Dominant
Lethal Test)
Decamethylcyclopentasilo
xane
541-02-6
negative
inhalation
rat
OECD Guideline 486
(Unscheduled DNA Synthesis
(UDS) Test with Mammalian
Liver Cells in vivo)
Decamethylcyclopentasilo
xane
541-02-6
negative
inhalation: vapour
rat
OECD Guideline 474
(Mammalian Erythrocyte
Micronucleus Test)
Dodecamethylcyclohexasi
loxane
540-97-6
negative
intraperitoneal
mouse
OECD Guideline 474
(Mammalian Erythrocyte
Micronucleus Test)
Carcinogenicity
No data available.