Certifications 2

SDS No.: 164824 V007.0
LOCTITE SI 5368 BK CR310ML EGF
Page 12 of 17
Reproductive toxicity:
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result / Value
Test type
Route of
application
Species
Method
octamethylcyclotetrasilox
ane
556-67-2
NOAEL P 300 ppm
NOAEL F1 300 ppm
two-
generation
study
inhalation
rat
equivalent or similar to
OECD Guideline 416 (Two-
Generation Reproduction
Toxicity Study)
Methyltriacetoxysilane
4253-34-3
NOAEL P >= 1.000 mg/kg
NOAEL F1 >= 1.000 mg/kg
screening
oral: gavage
rat
OECD Guideline 422
(Combined Repeated Dose
Toxicity Study with the
Reproduction /
Developmental Toxicity
Screening Test)
Decamethylcyclopentasilo
xane
541-02-6
NOAEL P >= 160 ppm
NOAEL F1 >= 160 ppm
NOAEL F2 >= 160 ppm
two-
generation
study
inhalation:
vapour
rat
EPA OPPTS 870.3800
(Reproduction and Fertility
Effects)
Dodecamethylcyclohexasi
loxane
540-97-6
NOAEL P 1.000 mg/kg
NOAEL F1 1.000 mg/kg
screening
oral: gavage
rat
OECD Guideline 422
(Combined Repeated Dose
Toxicity Study with the
Reproduction /
Developmental Toxicity
Screening Test)
STOT-single exposure:
No data available.
STOT-repeated exposure::
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result / Value
Route of
application
Exposure time /
Frequency of
treatment
Species
Method
octamethylcyclotetrasilox
ane
556-67-2
LOAEL 35 ppm
inhalation
6 h nose only
inhalation
5 days/week for 13
weeks
rat
OECD Guideline 412
(Repeated Dose
Inhalation Toxicity:
28/14-Day)
octamethylcyclotetrasilox
ane
556-67-2
NOAEL 960 mg/kg
dermal
3 w
5 d/w
rabbit
equivalent or similar to
OECD Guideline 410
(Repeated Dose Dermal
Toxicity: 21/28-Day
Study)
Methyltriacetoxysilane
4253-34-3
NOAEL 50 mg/kg
oral: gavage
28-51 d
daily
rat
OECD Guideline 422
(Combined Repeated
Dose Toxicity Study with
the Reproduction /
Developmental Toxicity
Screening Test)
Decamethylcyclopentasilo
xane
541-02-6
NOAEL >= 1.000
mg/kg
oral: gavage
13 w
daily
rat
OECD Guideline 408
(Repeated Dose 90-Day
Oral Toxicity in Rodents)
Dodecamethylcyclohexasi
loxane
540-97-6
NOAEL 1.000 mg/kg
oral: gavage
29 d
daily, 7 d/w
rat
OECD Guideline 422
(Combined Repeated
Dose Toxicity Study with
the Reproduction /
Developmental Toxicity
Screening Test)
Aspiration hazard:
No data available.