SDS

11
CONTINUED: SECTION 11. TOXICOLOGICAL INFORMATION
-1,3-Dioxolan-2-one : Negative reactions were observed in vitro (mammalian cell gene mutation assay (OECD Guideline 476, GLP)).
-Lithium hexafluorophosphate(1-) : Negative reactions were observed in both in vivo (Mammalian Erythrocyte Micronucleus
test(OECD Guideline 474)) and in vitro (Bacterial Reverse Mutation Assay(OECD Guideline 471, GLP)).
-Ethyl acetate : Negative reactions were observed in both in vitro(Bacterial Reverse Mutation Assay(OECD Guideline 471)) and in
vivo (Mammalian Erythrocyte Micronucleus Test(OECD Guideline 474)).
-Carbon black : Negative reactions were observed in both in vitro(Bacterial gene mutation test(OECD TG 471, GLP), Chromosomal
aberrations test(OECD TG 476)) and in vivo(DNA damage and/or repair test).
-Lithium carbonate;Lithane : Negative reactions were observed in vitro (Bacterial Reverse Mutation Assay(OECD Guideline 471,
GLP)).
-1-Methyl-2-pyrrolidinone : Negative reactions were observed in both in vitro (Chromosomal aberrations test (OECD Guideline 476,
GLP)) and in vivo (Mammalian Erythrocyte Micronucleus Test (OECD Guideline 474, GLP)).
Reproductive toxicity :
-Copper : In reproductive toxicity with rats, there were no effects considered (up to 1500 ppm). (OECD TG 416, GLP)
-Aluminum : No reproduction, breeding and early post-natal developmental toxicity was observed in rats at 1000 mg/kg bw for males
and females. (OECD TG 422, GLP)(Aluminium chloride; read across)
-Lithium hexafluorophosphate(1-) : In the two-generation reproductive toxicity with rats, no effects observed on reproductive toxicity.
(male/female)(OECD Guideline 416, GLP)(OECD Guideline 414)(Information on major hydrolysis product of the registered
substance (released rapidly on contact with water/moisture))
-Carbon black : No adverse effects on the reproductive function are expected.(OECD TG 414
Specific target organ toxicity (single exposure) :
-Fe : If inhaled, iron is a local irritant to the lung and gastrointestinal tract.
-Copper : All animals showed expected gains in bodyweight over the study period and there were no abnormalities noted
at necropsy. (OECD TG 423, GLP)
-Aluminum : In test using rats, Clinical signs of depression, laboured respiration, piloerection and hunched appearance
was noted at the highest dose 15900 mg/kg. Macroscopic examination at the end of the observation period did not reveal
any aluminum-related changes of the internal organs of the aluminum treated animals compared to the control group.
(OECD TG 401)(Fumed alumina; read across)
-Polyethylene : No test substance-related toxic effects were observed in an acute oral toxicity study with rats.
-Lithium hexafluorophosphate(1-) : Clinical signs observed during the study period were lethargy, hunched posture,
uncoordinated movements, piloerection at 300 mg/kg, hunched posture, piloerection at 50 mg/kg. The surviving animals
had recovered from the symptoms by Day 3.(OECD Guideline 423, GLP)
- Carbon black : No effect on endothelins or blood pressure was observed after exposure to carbon black. There were also
no effects on body temperature and activity of the animals.
-Nickel; Raney nickel : In the acute oral toxicity using rat, there were no effects on clinical signs, systemic toxicity.
(OECD Guideline 401, GLP)
Specific target organ toxicity (repeat exposure) :
-Fe : Rats were exposed to metallic iron as carbonyl iron via their feed (2.5%) for 2, 4, 6, or 9 weeks. This resulted in a strong increase
of non-heme iron in the liver and clear lipid peroxidation in the liver and the mucosa of the duodenum. No evidence for DNA
breakage were found. What follows is the original abstract of the publication. (carbonyl iron)
-Copper : In test with rats for 92 days, there were no mortalities or signs of clinical toxicity observed in any of the test species during
the duration of the study. Opthalmoscopic examinations revealed no abnormalities at any dose level tested. At gross pathology,
significant decreases in heart and kidney weight were noted in the high dose males in the thymus and kidneys of high dose females.
(GLP)
-Aluminum : On occasion workers chronically exposed to aluminum-containing dusts or fumes have developed severe pulmonary
reactions including fibrosis, emphysema and pneumothorax.
-Polyethylene : No significant adverse effects were observed in subchronic (90-day) oral toxicity study with rats and dogs.
-Lithium hexafluorophosphate(1-) : According to expert review of fluoride intake and effects on human health, fluoride intake in
drinking water at levels close to or above 4 mg/l is associated with dental fluorosis and perhaps also bone fluorosis and/or
weakening.; Damage to dental enamel recorded: especially notable in young animals, which also showed atrophy of respiratory
organs/tissues with local oedema of bronchial mucosa. Older animals showed peribronchial hyperplasia. Animals around 1 year in
age showed cavity formation in their bones.(Information on major hydrolysis product of the registered substance (released rapidly on
contact with water/moisture))(OECD Guideline 412)
-Carbon black : Mice were continuously fed various types of carbon black in massive quantities (10% in diet) for 12 to 18 months.
This led to no detectable changes from the normal in the organs and tissues of the mice fed.
-Nickel; Raney nickel : In nickel plating industry, exposure to nickel containing vapors has been reported to be assoc with asthma.
Aspiration Hazard : Not available