Specifications

The Patent Office Journal 17/12/2010
4530
(12) PATENT APPLICATION PUBLICATION (21) Application No.3934/CHENP/2010 A
(19) INDIA
(22) Date of filing of Application :24/06/2010 (43) Publication Date : 17/12/2010
(54) Title of the invention : SYNTHETIC INTERMEDIATES, PROCESS FOR PREPARING PYRROLYLHEPTANOIC ACID
DERIVATIVES THEREFROM
(51) International classification :C07D207/34
(31) Priority Document No :10 2007 0138166
(32) Priority Date :27/12/2007
(33) Name of priority country :Republic of Korea
(86) International Application No
Filing Date
:PCT/KR08/007350
:12/12/2008
(87) International Publication No
:WO 2009/084827
A3
(61) Patent of Addition to Application
Number
Filing Date
:NA
:NA
(62) Divisional to Application Number
Filing Date
:NA
:NA
(71)Name of Applicant :
1)DONG-A PHARM. CO., LTD.
Address of Applicant :252, YONGDU-DONG,
DONGDAEMUN-KU, SEOUL 130-070. Republic of Korea
(72)Name of Inventor :
1)KIM, MOON-SUNG
2)YOO, MOO-HI
3)RHEE, JAE-KEOL
4)KIM, YONG-JIK
5)PARK, SEONG-JIN
6)CHOI, JUN-HO
7)SUNG, SI-YOUNG
8)LIM, HONG-GYU
9)CHA, DAE-WON
(57) Abstract :
There are provided intermediates used to prepare a derivative, (3R,5R)-7-[2-(4-fluorphenyl)-5-isopropyl-3-phenyl-4-
(phenylcarbamoyl)-IH-pyrrol-l-yl]-3,5-di hydroxyheptanoic acid, which has an effect to suppress cholesterol in blood, and a process
for preparing pyrrolylheptanoic acid derivatives therefrom. In accordance with the present invention, the 5-(4-fiuorphenyl)-2-
isopropyl-4-phenyl-IH-pyrrole-3-carbonyl derivative is provided as one of the novel synthetic intermediates that are used to prepare
pyrrolylheptanoic acid derivatives including a derivative, (3R,5R)-7-[2-(4-fluorphenyl)-5-isopropy-3-phenyl-4-(phenylcarbamoyl)-IH-
pyrrol-l-yl]-3,5-di hydroxyheptanoic acid. Therefore the (3R,5R)-7-[2-(4-fluorphenyl)-5-isopropy-3-phenyl-4-(phenylcarbamoyl)-IH-
pyrrol-l-yl]-3,5-di hydroxyheptanoic acid derivative may be prepared from the carbonyl derivative in a high yield for a short time
period under a moderate condition.
No. of Pages : 17 No. of Claims : 10