Specifications

The Patent Office Journal 17/12/2010
4575
(12) PATENT APPLICATION PUBLICATION (21) Application No.3977/CHENP/2010 A
(19) INDIA
(22) Date of filing of Application :25/06/2010 (43) Publication Date : 17/12/2010
(54) Title of the invention : BETA-LACTAMASE INHIBITORS
(51) International classification :C07D471/08
(31) Priority Document No :61/011,533
(32) Priority Date :18/01/2008
(33) Name of priority country :U.S.A.
(86) International Application No
Filing Date
:PCT/US2009/031047
:15/01/2009
(87) International Publication No :WO 2009/091856 A3
(61) Patent of Addition to Application
Number
Filing Date
:NA
:NA
(62) Divisional to Application Number
Filing Date
:NA
:NA
(71)Name of Applicant :
1)MERCK SHARP & DOHME CORP.
Address of Applicant :126 EAST LINCOLN AVENUE,
RAHWAY, NEW JERSEY 07065-0907. U.S.A.
(72)Name of Inventor :
1)BLIZZARD, TIMOTHY, A.
2)CHEN, HELEN
3)GUDE, CANDIDO
4)HERMES, JEFFREY, D.
5)IMBRIGLIO, JASON, E.
6)KIM, SEONGKON
7)WU, JANE, Y.
8)HA, SOOKHEE
9)MORTKO, CHRISTOPHER,J.
10)MANGION, IAN
11)RIVERA, NELO
12)RUCK, REBECCA, T.
13)SHEVLIN, MICHAEL
(57) Abstract :
Substituted bicyclic beta-lactams of Formula I: (I), are β-lactamase inhibitors, wherein a, X, R1 and R2 are defined herein. The
compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with β-
lactam antibiotics. In particular, the compounds can be employed with a β-lactam antibiotics (e.g., imipenem, piperacillin, or
ceftazidime) against microorganisms resistant to β-lactam antibiotics due to the presence of the β-lactamases. FIG.1.
No. of Pages : 146 No. of Claims : 36