SDS

SDS 672
PRESTONE® EXTENDED LIFE HEAVY DUTY
ANTIFREEZE/COOLANT (YELLOW OAT) PRE-DILUTED 50%
Date Prepared: 08/05/2016
Page 5 of 8
11. Toxicological Information
POTENTIAL HEALTH EFFECTS:
ACUTE HAZARDS:
INHALATION: May cause irritation of the nose and throat with headache, particularly from mists. High vapor concentrations
caused, for example, by heating the material in an enclosed and poorly ventilated workplace, may produce nausea, vomiting,
headache, dizziness and irregular eye movements.
SKIN CONTACT: No evidence of adverse effects from available information.
EYE CONTACT: Liquid, vapors or mist may cause discomfort in the eye with persistent conjunctivitis, seen as slight excess
redness or conjunctiva. Serious corneal injury is not anticipated.
INGESTION: May cause abdominal discomfort or pain, nausea, vomiting, dizziness, drowsiness, malaise, blurring of vision,
irritability, back pain, decrease in urine output, kidney failure, and central nervous system effects, including irregular eye
movements, convulsions and coma. Cardiac failure and pulmonary edema may develop. Severe kidney damage which may be
fatal may follow the swallowing of ethylene glycol. A few reports have been published describing the development of
weakness of the facial muscles, diminishing hearing, and difficulty with swallowing, during the late stages of severe poisoning.
CHRONIC EFFECTS: Prolonged or repeated inhalation exposure may produce signs of central nervous system involvement,
particularly dizziness and jerking eye movements. Prolonged or repeated skin contact may cause skin sensitization and an
associated dermatitis in some individuals. Ethylene glycol has been found to cause birth defects in laboratory animals. The
significance of this finding to humans has not been determined. 2-Ethyl Hexanoic Acid, Sodium Salt is suspected of causing
developmental effects based on animal data.
CARCINOGENICITY LISTING: None of the components of these products is listed as a carcinogen or suspected carcinogen
by IARC, NTP, ACGIH, or OSHA.
ACUTE TOXICITY VALUES:
Ethylene Glycol: LD50 Oral Rat: 4700 mg/kg
LD50 Skin Rabbit: 9530 mg/kg
Diethylene Glycol: LD50 Oral Rat: 12,565 mg/kg
LD50 Skin Rabbit: 11,890 mg/kg
SIGNIFICANT LABORATORY DATA WITH POSSIBLE RELEVANCE TO HUMAN HEALTH:
Ethylene glycol has been shown to produce dose-related teratogenic effects in rats and mice when given by gavage or in
drinking water at high concentrations or doses. Also, in a preliminary study to assess the effects of exposure of pregnant rats
and mice to aerosols at concentrations 150, 1,000 and 2,500 mg/m3 for 6 hours a day throughout the period of organogenesis,
teratogenic effects were produced at the highest concentrations, but only in mice. The conditions of these latter experiments did
not allow a conclusion as to whether the developmental toxicity was mediated by inhalation of aerosol, percutaneous absorption
of ethylene glycol from contaminated skin, or swallowing of ethylene glycol as a result of grooming the wetted coat. In a
further study, comparing effects from high aerosol concentration by whole-body or nose-only exposure, it was shown that nose-
only exposure resulted in maternal toxicity (1,000 and 2,500 mg/m3) and developmental toxicity in with minimal evidence of
teratogenicity (2,500 mg/m3). The no-effects concentration (based on maternal toxicity) was 500 mg/m3. In a further study in
mice, no teratogenic effects could be produced when ethylene glycol was applied to the skin of pregnant mice over the period of
organogenesis. The above observations suggest that ethylene glycol is to be regarded as an animal teratogen; there is currently
no available information to suggest that ethylene glycol caused birth defects in humans. Cutaneous application of ethylene
glycol is ineffective in producing developmental toxicity; exposure to high aerosol concentration is only minimally effective in
producing developmental toxicity; the major route for producing developmental toxicity is perorally.