SDS

SAMSUNG SDI Co., Ltd.
Date: Jan 7
th
2020 Revision no.: 01
ELG(P11P35-11-N01,3.7L1200SPA)
Page 15 of 22
Escherichia coli.
- Carbonic acid diethyl ester : In vitro mammalian cell micronucleus test, positive reaction was
observed.Diethyl carbonate showed clear evidence of genotoxic activity. (OECD TG 487, GLP) But,
the substance is not classfied as mutagenicity because there are no datas in vivo genetic toxicity test.
- Lithium hexafluorophosphate(1-) : Negative reactions were observed in both in vivo (Mammalian
Erythrocyte Micronucleus test(OECD Guideline 474)) and in vitro (Bacterial Reverse Mutation
Assay(OECD Guideline 471, GLP)).
- Butanedinitrile : Negative reactions were observed in both in vivo (Mammalian Erythrocyte
Micronucleus test(OECD Guideline 474, GLP)) and in vitro (Bacterial Reverse Mutation Assay(OECD
Guideline 471, GLP)).
- Carbon black : Negative reactions were observed in both in vitro(Bacterial Reverse Mutation Assay
test(OECD Guideline 471, GLP)and in vivo(DNA damage and/or repair test).
- Fe : In mammalian cell gene mutation assay electrolytic iron, positive carbonyl iron exhibited a
cytotoxic and mutagenic response (OECD TG 476)
- Manganese : In the mammalian cell gene mutation assay, the result of the assay was negative.
(Read across; Manganese chloride)(OECD TG 476, GLP)
Reproductive toxicity :
- Cobalt hydroxide oxide : In the reproduction toxicity test using rat, no effects were observed.(OECD
Guideline 408, GLP)
- Aluminum : No reproduction, breeding and early post-natal developmental toxicity was observed in
rats at 1000 mg/kg bw for males and females. (OECD TG 422, GLP)(Aluminium chloride; read across)
- Copper : In reproductive toxicity with rats, there were no effects considered (up to 1500 ppm).
(OECD TG 416, GLP)
- Tricobalt tetraoxide : No effect on cultured embryos derived from chronically treated male rats.
- Carbonic acid diethyl ester : In multigeneration study with rats, there were no indications of diethyl
carbonate having an organotropic effect.
- Lithium hexafluorophosphate(1-) : In the two-generation reproductive toxicity with rats, no effects
observed on reproductive toxicity. (male/female)(OECD Guideline 416, GLP)(OECD Guideline
414)(Information on major hydrolysis product of the registered substance (released rapidly on contact
with water/moisture))
- Carbon black : No adverse effects on the reproductive function are expected.(OECD Guideline 414)
Specific target organ toxicity (single exposure) :
- Aluminum : In test using rats, Clinical signs of depression, laboured respiration, piloerection and
hunched appearance was noted at the highest dose 15900 mg/kg. Macroscopic examination at the
end of the observation period did not reveal any aluminium-related changes of the internal organs of
the aluminium treated animals compared to the control group. (OECD TG 401)(Fumed alumina; read
across)
- Copper : All animals showed expected gains in bodyweight over the study period and there were no
abnormalities noted at necropsy. (OECD TG 423, GLP)
- Tricobalt tetraoxide : No clinical signs were observed during the study with rats.(OECD TG 402, GLP)
- Polyethylene : No test substance-related toxic effects were observed in an acute oral toxicity study
with rats.
- Carbonic acid diethyl ester : In acute oral toxicity test with rats, no symptoms developed.
- Lithium hexafluorophosphate(1-) : Clinical signs observed during the study period were lethargy,
hunched posture, uncoordinated movements, piloerection at 300 mg/kg, hunched posture, piloerection
at 50 mg/kg. The surviving animals had recovered from the symptoms by Day 3.(OECD Guideline 423,
GLP)
- Carbon black : No effect on endothelins or blood pressure was observed after exposure to carbon
black. There were also no effects on body temperature and activity of the animals.
- Fe : If inhaled, iron is a local irritant to the lung and gastrointestinal tract.
- Nickel; Raney nickel : In the acute oral toxicity using rat, there were no effects on clinical signs,
systemic toxicity.(OECD Guideline 401, GLP)