Technical data

41
“PRECISION/hq” Kit
The “PRECISION/hq” Offline Kit, in contrast to
the “PRECISION/lq” Kit, due to the higher ca-
pacity 25 ml syringes (dosing precision ± 0.25
ml), allows withdrawing/storing higher volume of
sample within a shorter time. E.g. when more
than 7 ml media has to be collected the
“PRECISION/lq” Kit needs to withdraw media
twice while the “PRECISION/hq” Kit can with-
draw up to 20 ml at once. The system com-
prises of:
1.) Fully USP/EP compliant sampling station
with automatic sample withdraw height ad-
justment and 7 stainless steel (316) sam-
ple withdraw tubes
2.) 7-channel syringe pump SP 725/25 with 25
ml syringes and mechanically operated
valves
3.) FRL 720 7-channel “silent” Autosampler
with x/y driven arm in “corrosion reduced
design” for collection of up to 25 sampling
intervals into 10 ml glass tubes, sealed
1.2/4.0 ml HPLC vials or 17 sampling in-
tervals into 25 ml glass tubes as well as
support arm to hold a rack.
4.) Tubing/Connector Kit, Teflon
5.) System pre-configuration
6.) Upgraded micro-controller for DT 820 se-
ries to control the complete Offline System
Not included: DT 820 dissolution tester and
collection rack.
Operation principle:
The stainless steel (optional Titanium) sample
withdraw tubes are driven into the media (ex-
actly midway between the top of the media and
the top of the rotating Basket or Paddle)
only while the sample is withdrawn – not to
change the hydrodynamic inside the vessel –
as described in the USP and EP.
Optional the sample withdraw system can be
equipped with electronic temperature sensors
for each vessel to archive media temperature
documentation for each test-station.
The connected 7-channel syringe Pump SP
725/25 sucks the media through the filter and
Teflon tubing to the syringe, passing a motor
driven, mechanical 4-way switching valve with
inert interior. Then the valves switch and the
new Teflon coated, 2-part pistons push the
sample into the waiting glass tubes or
sealed/unsealed HPLC vials (membrane pierc-
ing standard).
The FRL 720 Autosampler allows storage of up
to 25 (glass tubes of 10 ml-, HPLC vials of 1.5
or 4.0 ml capacity) or 17 (glass tubes of 25 ml
capacity) sampling intervals.
Optionally cooled racks for HPLC vials are
available.
After sample collection the 316 stainless steel
tubes (optionally Titanium) of the Autosampler
drive down into the replacement media inside
the acrylic glass reservoir which refills after
each media replacement interval automatically
by two integrated 1-channel peristaltic pumps.
The syringes will transfer the desired volume to
the test-stations to keep the media volume
within the USP/EP specified ± 1% limits.
The FRL 720 in combination with the syringe
pump and 10/25 ml glass tubes allows auto-
mated dilution of the sample in the 1:1, 1:2, 1:5
and 1:10 relations.
“PRECISION/hq” Offline Kit, 7-channel
15-147-0000
(storage/precision doses into tubes & HPLC Vials, media replacement and HPLC
Vial membrane piercing)