Specification

Safety Data Sheet
Sikaflex® + Construction Sealant
Revision Date 10/13/2022
Print Date 10/13/2022
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Solvent extracts of carbon black were used in one study of
rats in which skin tumors were found after dermal application
and several studies of mice in which sarcomas were found
following subcutaneous injection. IARC concluded that there
was "sufficient evidence" that carbon black extracts can cause
cancer in animals (Group 2B).
ICGIH CANCER CLASSIFICATION: Confirmed Animal Car-
cinogen with Unknown Relevance to Humans (Category A3
Carcinogen).
ASSESSMENT: Applying the guidelines of self-classification
under the Globally Harmonized System of Classification and
Labeling of Chemicals, carbon black is not classified as a
carcinogen. Lung tumors are induced in rats as a result of
repeated exposure to inert, poorly soluble particles like carbon
black and other poorly soluble particles. Rats tumors are a
result of a secondary non-genotoxic mechanism that has
questionable relevance for classification in humans. In support
of this opinion, the CLP Guidance for Specific Target Organ
Toxicity - Repeated Exposure (STOT-RE), cites lung overload
under mechanisms not relevant to humans. Human health
studies show that exposure to carbon black does not increase
the risk to carcinogenicity.
Titanium dioxide (13463-67-7)
In lifetime inhalation studies of rats, airborne respirable-size
titanium dioxide particles have shown to cause an increase in
lung tumors at concentrations associated with substantial
particle lung burdens and consequential pulmonary overload
and inflammation. The potential for these adverse health ef-
fects appears to be closely related to the particle size and the
amount of the exposed surface area that comes into contact
with the lung. However, tests with other laboratory animals
such as mice and hamsters, indicate that rats are significantly
more susceptible to the pulmonary overload and inflammation
that causes lung cancer. Epidemiological studies do not sug-
gest an increased risk of cancer in humans from occupational
exposure to titanium dioxide. Titanium dioxide has been char-
acterized by IARC as possibly carcinogenic to humans (Group
2B) through inhalation (not ingestion). It has not been charac-
terized as a potential carcinogen by either NTP or OSHA.
Quartz (14808-60-7): This classification is relevant when ex-
posed to Quartz (silicon dioxide) in dust or powder form only,
including cured product that is subject to sanding, grinding,
cutting, or other surface preparation activities.