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STANLEY CHALKS SDS

PAGE 7 OF 11

11. TOXICOLOGICAL INFORMATION (Continued)

TOXICITY DATA (continued):

CARBON BLACK (continued):

TCLo (Inhalation-Rat) 50 mg/m

/13 weeks-intermittent:

Lungs, Thorax, or Respiration: other changes;

Biochemical: Metabolism (Intermediary): other, effect

on inflammation or mediation of inflammation

TCLo (Inhalation-Rat) 7 mg/m3/6 hours/13 weeks-

intermittent: Sense Organs and Special Senses

(Olfaction): effect, not otherwise specified;

Biochemical: Metabolism (Intermediary): effect on

inflammation or mediation of inflammation

TCLo (Inhalation-Mouse) 50 mg/m

/6 hours: Sense

Organs and Special Senses (Olfaction): effect, not

otherwise specified

TCLo (Inhalation-Mouse) 1 mg/m

/13 weeks-intermittent:

Lungs, Thorax, or Respiration: other changes;

Biochemical: Metabolism (Intermediary): effect on

inflammation or mediation of inflammation

TCLo (Inhalation-Mouse) 1 mg/m

/13 weeks-intermittent:

Lungs, Thorax, or Respiration: other changes; Lungs,

Thorax, or Respiration: changes in lung weight;

Biochemical: Metabolism (Intermediary): effect on

inflammation or mediation of inflammation

TCLo (Inhalation-Mouse) 7 mg/m

/6 hours/13 weeks-

intermittent: Sense Organs and Special Senses

(Olfaction): effect, not otherwise specified;

Biochemical: Metabolism (Intermediary): effect on

inflammation or mediation of inflammation

TCLo (Inhalation-Hamster) 7 mg/m

/13 weeks-

intermittent: Lungs, Thorax, or Respiration: other

changes; Biochemical: Metabolism (Intermediary):

effect on inflammation or mediation of inflammation

TCLo (Inhalation-Hamster) 50 mg/m

/6 hours/13 weeks-

intermittent: Sense Organs and Special Senses

(Olfaction): effect, not otherwise specified

C.I. PIGMENT BLUE 29:

(Oral-Rat) 10 gm/kg

(Oral-Mouse) 10 gm/kg

TDLo (Oral-Rat) 450 mg/kg/90 days-continuous:

Gastrointestinal: other changes;

Kidney/Ureter/Bladder: other changes

CRYSTALLINE SILICA, CRYSTALLINE-QUARTZ:

LCLo (Inhalation-Human) 300 mg/m

/10 years-

intermittent: Systemic effects

TCLo (Inhalation-Human) 16 mppcf/8 hours/17.9 years-

intermittent: Pulmonary system effects

TCLo (Inhalation-Rat) 58 mg/m

/13 weeks-intermittent:

Lungs, Thorax, or Respiration: other changes;

Endocrine: changes in thymus weight; Blood:

changes in leukocyte (WBC) count

CRYSTALLINE SILICA, CRYSTALLINE-QUARTZ

(continued):

TCLo (Inhalation-Rat) 50 mg/m

/6 hours/71 weeks-

intermittent: Carcinogenic effects

TCLo (Inhalation-Rat) 80 mg/m

/26 weeks-intermittent:

Lungs, Thorax, or Respiration: fibrosis, focal

(pneumoconiosis); Blood: changes in spleen;

Immunological Including Allergic: decrease in cellular

immune

TCLo (Inhalation-Rat) 108 mg/m

/6 hours/3 days-

intermittent: Biochemical: Enzyme inhibition, induction,

or change in blood or tissue levels: phosphatases,

Enzyme inhibition, induction, or change in blood or

tissue levels: other oxidoreductases, Metabolism

(Intermediary): other proteins

TCLo (Inhalation-Mouse) 1475 g/m

/8 hours/21 weeks-

intermittent: Lungs, Thorax, or Respiration: other

changes

TCLo (Inhalation-Mouse) 4932 g/m

/24 hours/39 weeks-

continuous: Endocrine: changes in spleen weight;

Immunological Including Allergic: decrease in humoral

immune response

TCLo (Inhalation-Guinea Pig) 28 mg/m

/3 weeks-

continuous: Lungs, Thorax, or Respiration: other

changes, changes in lung weight; Biochemical: Enzyme

inhibition, induction, or change in blood or tissue levels:

other

TDLo (Intraperitoneal-Rat) 45 mg/kg: Carcinogenic effects

TDLo (Intratracheal-Rat) 90 mg/kg: Equivocal tumorigenic

agent

TDLo (Intratracheal-Rat) 90 mg/kg: AR

TDLo (Intratracheal-Rat) 111 mg/kg: Carcinogenic effects

TDLo (Intratracheal-Rat) 111 mg/kg: AR

TDLo (Intratracheal-Rat) 100 mg/kg/19 weeks-intermittent:

Tumorigenic: equivocal tumorigenic agent by RTECS

criteria; Lungs, Thorax, or Respiration: tumors

TDLo (Intrapleural-Rat) 90 mg/kg: Carcinogenic effects

TDLo (Intrapleural-Hamster) 83 mg/kg: Tumorigenic:

neoplastic by RTECS criteria, tumors at site of

application

TDLo (Implant-Rat) 900 mg/kg: Neoplastic effects

TDLo (Implant-Mouse) 4000 mg/kg: Tumorigenic:

equivocal tumorigenic agent by RTECS criteria; Kidney,

Ureter, Bladder: tumors

TDLo (Implant-Mouse) 4000 mg/kg: Equivocal tumorigenic

agent

TDLo (Intravenous-Rat) 90 mg/kg: Tumorigenic: equivocal

tumorigenic agent by RTECS criteria; Blood: lymphoma,

including Hodgkin's disease

CRYSTALLINE SILICA, CRYSTALLINE-QUARTZ

(continued):

TD (Intraperitoneal-Rat) 90 mg/kg/4 weeks-intermittent:

Equivocal tumorigenic agent

TD (Intraperitoneal-Rat) 450 mg/kg/4 weeks-intermittent:

Neoplastic effects

TD (Implant-Rat) 4554 mg/kg: Equivocal tumorigenic agent

TD (Intrapleural-Rat) 200 mg/kg: Equivocal tumorigenic

agent

TD (Intrapleural-Rat) 100 mg/kg: Carcinogenic effects

TD (Intrapleural-Rat) 100 mg/kg: Neoplastic effects

TD (Intrapleural-Rat) 100 mg/kg: Tumorigenic: equivocal

tumorigenic agent by RTECS criteria; Lungs, Thorax, or

Respiration: fibrosis, focal (pneumoconiosis), tumors

LDLo (Intravenous-Rat) 90 mg/kg

LDLo (Intratracheal-Rat) 200 mg/kg

LDLo (Intravenous-Mouse) 40 mg/kg

LDLo (Intravenous-Dog, adult) 20 mg/kg

Micronucleus test (Human-Lung) 40 g/cm

Micronucleus test (Hamster-Lung) 160 g/cm

HEMATITE/IRON OXIDE:

TDLo (Intratracheal-Rat) 12 mg/kg: Lungs, Thorax, or

Respiration: other changes; Biochemical: Enzyme

inhibition, induction, or change in blood or tissue levels:

multiple enzyme effects

TCLo (Inhalation-Rat) 3900 mg/m

/6 hours/68 weeks-

intermittent: Lungs, Thorax, or Respiration: fibrosis

(interstitial)

TCLo (Inhalation-Dog) 3900 mg/m

/6 hours/68 weeks-

intermittent: Lungs, Thorax, or Respiration: fibrosis

(interstitial)

MAGNESIUM CARBONATE/TALC:

(Oral-Rat) 7000 mg/kg

(Oral-Mouse) 8000 mg/kg

(Intraperitoneal-Mouse) 1033 mg/kg

TCLo (Inhalation-Rat) 76 mg/m

/4 hours: Cardiac: pulse

rate increase, without fall in BP; Liver: liver function tests

impaired; Kidney/Ureter/Bladder: other changes in urine

composition

TCLo (Inhalation-Rat) 76 mg/m

/4 hours: Blood: changes

in serum composition (e.g. TP, bilirubin, cholesterol);

Biochemical: Enzyme inhibition, induction, or change in

blood or tissue levels: phosphatases

TDLo (Unreported-Mammal-Species Unspecified) 18,000

mg/kg/7 days-intermittent: Gastrointestinal: other

changes; Related to Chronic Data: death

CARCINOGENIC POTENTIAL OF COMPONENTS: The components of these products are listed by agencies tracking the

carcinogenic potential of chemical compounds, as follows:

CARBON BLACK: ACGIH TLV-A3 (Confirmed Animal Carcinogen with Unknown Relevance to Humans); IARC-2B (Possibly Carcinogenic to Humans), MAK-3B (Substances for Which in

vitro Tests or Animal Studies Have Yielded Evidence of Carcinogenic Effects that is Not Sufficient for Classification of the Substance in One of the Other Categories); In the Presence of

PAHS: NIOSH-Ca (Potential Occupational Carcinogen, with No Further Categorization)

CRYSTALLINE SILICA: ACGIH TLV-A2 (Suspected Human Carcinogen); IARC-1 (Carcinogenic to Humans); Respirable: MAK-1 (Substances that Cause Cancer in Man and Can Be

Assumed to Make a Significant Contribution to Cancer Risk); NIOSH-Ca (Potential Occupational Carcinogen, with No Further Categorization); Respirable: NTP-K (Known to Be a Human

Carcinogen)

IRON OXIDE/HEMATITE: ACGIH TLV-A4 (Not Classifiable as a Human Carcinogen); IARC-3 (Unclassifiable as to Carcinogenicity in Humans); MAK-3B (Substances for Which in vitro Tests

or Animal Studies Have Yielded Evidence of Carcinogenic Effects that is Not Sufficient for Classification of the Substance in One of the Other Categories)

MAGNESIUM CARBONATE (TALC containing no asbestos fibers): ACGIH TLV-A4 (Not Classifiable as a Human Carcinogen); IARC-3 (Unclassifiable as to Carcinogenicity in Humans);

Respirable: MAK-3B (Substances for Which in vitro Tests or Animal Studies Have Yielded Evidence of Carcinogenic Effects that is Not Sufficient for Classification of the Substance in One of

the Other Categories)

The remaining components of this product are not found on the following lists: U.S. EPA, U.S. NTP, U.S. OSHA, U.S.

NIOSH, GERMAN MAK, IARC, or ACGIH and therefore are neither considered to be nor suspected to be cancer-causing

agents by these agencies.

IRRITANCY OF PRODUCT: These products may cause skin, eye and respiratory irritation.

SENSITIZATION TO THE PRODUCT: Components of these products are not known to cause human skin or respiratory

sensitization.

REPRODUCTIVE TOXICITY INFORMATION: The components of these products are not known to cause human

mutagenic, embryotoxic, teratogenic or reproductive toxicity in humans.

ACGIH BIOLOGICAL EXPOSURE INDICES: Currently, there are no ACGIH Biological Exposure Indices (BEIs) determined

for the components of these products.

12. ECOLOGICAL INFORMATION

ALL WORK PRACTICES MUST BE AIMED AT ELIMINATING ENVIRONMENTAL CONTAMINATION.

MOBILITY: These products have not been tested for mobility in soil; due to form they are not expected to be mobile.

PERSISTENCE AND BIODEGRADABILITY: These products have not been tested for persistence or biodegradability.

BIO-ACCUMULATION POTENTIAL: These products have not been tested for bio-accumulation potential.

ECOTOXICITY: These products have not been tested for aquatic or animal toxicity. All release to terrestrial, atmospheric

and aquatic environments should be avoided.