SDS

VIAL FLUID 2 (360 Vials)
VIAL FLUID 2 (360 Vials) MSDS
PAGE 7 OF 9
DEFINITIONS OF TERMS
A large number of abbreviations and acronyms appear on an MSDS. Some of these, which are commonly used, include the following:
CAS #: This is the Chemical Abstract Service Number that uniquely identifies each
constituent.
EXPOSURE LIMITS IN AIR:
CEILING LEVEL: The concentration that shall not be exceeded during any part of the
working exposure.
DFG MAK Germ Cell Mutagen Categories: 1: Germ cell mutagens which have been
shown to increase the mutant frequency in the progeny of exposed humans. 2: Germ
cell mutagens which have been shown to increase the mutant frequency in the progeny
of exposed mammals. 3A: Substances which have been shown to induce genetic
damage in germ cells of human of animals, or which produce mutagenic effects in
somatic cells of mammals in vivo and have been shown to reach the germ cells in an
active form. 3B: Substances which are suspected of being germ cell mutagens
because of their genotoxic effects in mammalian somatic cell in vivo; in exceptional
cases, substances for which there are no in vivo data, but which are clearly mutagenic
in vitro and structurally related to known in vivo mutagens. 4: Not applicable (Category
4 carcinogenic substances are those with non-genotoxic mechanisms of action. By
definition, germ cell mutagens are genotoxic. Therefore, a Category 4 for germ cell
mutagens cannot apply. At some time in the future, it is conceivable that a Category 4
could be established for genotoxic substances with primary targets other than DNA
[e.g. purely aneugenic substances] if research results make this seem sensible.) 5:
Germ cell mutagens, the potency of which is considered to be so low that, provided the
MAK value is observed, their contribution to genetic risk for humans is expected not to
be significant.
DFG MAK Pregnancy Risk Group Classification: Group A: A risk of damage to the
developing embryo or fetus has been unequivocally demonstrated. Exposure of
pregnant women can lead to damage of the developing organism, even when MAK and
BAT (Biological Tolerance Value for Working Materials) values are observed. Group
B: Currently available information indicates a risk of damage to the developing embryo
or fetus must be considered to be probable. Damage to the developing organism
cannot be excluded when pregnant women are exposed, even when MAK and BAT
values are observed. Group C: There is no reason to fear a risk of damage to the
developing embryo or fetus when MAK and BAT values are observed. Group D:
Classification in one of the groups A-C is not yet possible because, although the data
available may indicate a trend, they are not sufficient for final evaluation.
IDLH-Immediately Dangerous to Life and Health: This level represents a
concentration from which one can escape within 30-minutes without suffering escape-
preventing or permanent injury.
LOQ: Limit of Quantitation.
MAK: Federal Republic of Germany Maximum Concentration Values in the workplace.
NE: Not Established. When no exposure guidelines are established, an entry of NE is
made for reference.
NIC: Notice of Intended Change.
NIOSH CEILING: The exposure that shall not be exceeded during any part of the
workday. If instantaneous monitoring is not feasible, the ceiling shall be assumed as a
15-minute TWA exposure (unless otherwise specified) that shall not be exceeded at
any time during a workday.
NIOSH RELs: NIOSH’s Recommended Exposure Limits.
PEL-Permissible Exposure Limit: OSHA’s Permissible Exposure Limits. This
exposure value means exactly the same as a TLV, except that it is enforceable by
OSHA. The OSHA Permissible Exposure Limits are based in the 1989 PELs and the
June, 1993 Air Contaminants Rule (Federal Register
: 58: 35338-35351 and 58: 40191).
Both the current PELs and the vacated PELs are indicated. The phrase, “Vacated
1989 PEL,” is placed next to the PEL that was vacated by Court Order.
SKIN: Used when a there is a danger of cutaneous absorption.
STEL-Short Term Exposure Limit: Short Term Exposure Limit, usually a 15-minute
time-weighted average (TWA) exposure that should not be exceeded at any time
during a workday, even if the 8-hr TWA is within the TLV-TWA, PEL-TWA or REL-
TWA.
TLV-Threshold Limit Value: An airborne concentration of a substance that represents
conditions under which it is generally believed that nearly all workers may be repeatedly
exposed without adverse effect. The duration must be considered, including the 8-hour.
TWA-Time Weighted Average: Time Weighted Average exposure concentration for a
conventional 8-hr (TLV, PEL) or up to a 10-hr (REL) workday and a 40-hr workweek.
HAZARDOUS MATERIALS IDENTIFICATION SYSTEM HAZARD
RATINGS:
This rating system was developed by the National Paint and Coating
Association and has been adopted by industry to identify the degree of chemical
hazards.
HEALTH HAZARD
:
0 (Minimal Hazard
: No significant health risk, irritation of skin or eyes not anticipated.
Skin Irritation: Essentially non-irritating. PII or Draize = “0”. ): Eye Irritation:
Essentially non-irritating, or minimal effects which clear in < 24 hours [e.g. mechanical
irritation]. Draize = “0”. Oral Toxicity LD
50
Rat: < 5000 mg/kg. Dermal Toxicity LD
50
Rat
or Rabbit: < 2000 mg/kg. Inhalation Toxicity 4-hrs LC
50
Rat: < 20 mg/L.); 1 (Slight
Hazard: Minor reversible Injury may occur; slightly or mildly irritating. Skin Irritation:
Slightly or mildly irritating. Eye Irritation: Slightly or mildly irritating. Oral Toxicity LD
50
Rat: > 500-5000 mg/kg. Dermal Toxicity LD
50
Rat or Rabbit: > 1000-2000 mg/kg.
Inhalation Toxicity LC
50
4-hrs Rat: > 2-20 mg/L);2 (Moderate Hazard: Temporary or
transitory injury may occur. Skin Irritation: Moderately irritating; primary irritant;
sensitizer. PII or Draize > 0, < 5. Eye Irritation: Moderately to severely irritating and/or
corrosive; reversible corneal opacity; corneal involvement or irritation clearing in 8-21
days. Draize > 0, <
25. Oral Toxicity LD
50
Rat: > 50-500 mg/kg. Dermal Toxicity
LD
50
Rat or Rabbit: > 200-1000 mg/kg. Inhalation Toxicity LC
50
4-hrs Rat: > 0.5-2
mg/L.); 3 (Serious Hazard: Major injury likely unless prompt action is taken and
medical treatment is given; high level of toxicity; corrosive.
HAZARDOUS MATERIALS IDENTIFICATION SYSTEM HAZARD
RATINGS (continued):
HEALTH HAZARD (continued)
:
3 (continued): Skin Irritation: Severely irritating and/or corrosive; may destroy dermal
tissue, cause skin burns, dermal necrosis. PII or Draize > 5-8 with destruction of tissue.
Eye Irritation: Corrosive, irreversible destruction of ocular tissue; corneal involvement
or irritation persisting for more than 21 days. Draize > 80 with effects irreversible in 21
days. Oral Toxicity LD
50
Rat: > 1-50 mg/kg. Dermal Toxicity LD
50
Rat or Rabbit: > 20-
200 mg/kg. Inhalation Toxicity LC
50
4-hrs Rat: > 0.05-0.5 mg/L.); 4 (Severe Hazard:
Life-threatening; major or permanent damage may result from single or repeated
exposure. Skin Irritation: Not appropriate. Do not rate as a “4”, based on skin irritation
alone. Eye Irritation: Not appropriate. Do not rate as a “4”, based on eye irritation
alone. Oral Toxicity LD
50
Rat: < 1 mg/kg. Dermal Toxicity LD
50
Rat or Rabbit: < 20
mg/kg. Inhalation Toxicity LC
50
4-hrs Rat: < 0.05 mg/L).
FLAMMABILITY HAZARD
:
0 (Minimal Hazard-Materials that will not burn in air when exposure to a temperature of
815.5°C [1500°F] for a period of 5 minutes.); 1 (Slight Hazard-Materials that must be
pre-heated before ignition can occur. Material require considerable pre-heating, under
all ambient temperature conditions before ignition and combustion can occur, Including:
Materials that will burn in air when exposed to a temperature of 815.5°C (1500°F) for a
period of 5 minutes or less; Liquids, solids and semisolids having a flash point at or
above 93.3°C [200°F] (e.g. OSHA Class IIIB, or; Most ordinary combustible materials
[e.g. wood, paper, etc.]; 2 (Moderate Hazard-Materials that must be moderately heated
or exposed to relatively high ambient temperatures before ignition can occur. Materials
in this degree would not, under normal conditions, form hazardous atmospheres in air,
but under high ambient temperatures or moderate heating may release vapor in
sufficient quantities to produce hazardous atmospheres in air, Including: Liquids having
a flash-point at or above 37.8°C [100°F]; Solid materials in the form of course dusts that
may burn rapidly but that generally do not form explosive atmospheres; Solid materials
in a fibrous or shredded form that may burn rapidly and create flash fire hazards (e.g.
cotton, sisal, hemp; Solids and semisolids that readily give off flammable vapors.); 3
(Serious Hazard- Liquids and solids that can be ignited under almost all ambient
temperature conditions. Materials in this degree produce hazardous atmospheres with
air under almost all ambient temperatures, or, unaffected by ambient temperature, are
readily ignited under almost all conditions, including: Liquids having a flash point below
22.8°C [73°F] and having a boiling point at or above 38
° C [100 ° F] and below 37.8°C
[100°F] [e.g. OSHA Class IB and IC]; Materials that on account of their physical form or
environmental conditions can form explosive mixtures with air and are readily dispersed
in air [e.g., dusts of combustible solids, mists or droplets of flammable liquids]; Materials
that burn extremely rapidly, usually by reason of self-contained oxygen [e.g. dry
nitrocellulose and many organic peroxides]); 4 (Severe Hazard-Materials that will
rapidly or completely vaporize at atmospheric pressure and normal ambient
temperature or that are readily dispersed in air, and which will burn readily, including:
Flammable gases; Flammable cryogenic materials; Any liquid or gaseous material that
is liquid while under pressure and has a flash point below 22.8°C [73°F] and a boiling
point below 37.8°C [100°F] [e.g. OSHA Class IA; Material that ignite spontaneously
when exposed to air at a temperature of 54.4°C [130°F] or below [e.g. pyrophoric]).
PHYSICAL HAZARD
:
0 (Water Reactivity: Materials that do not react with water. Organic Peroxides:
Materials that are normally stable, even under fire conditions and will not react with
water. Explosives: Substances that are Non-Explosive. Unstable Compressed Gases:
No Rating. Pyrophorics: No Rating. Oxidizers: No “0” rating allowed. Unstable
Reactives: Substances that will not polymerize, decompose, condense or self-react.); 1
(Water Reactivity: Materials that change or decompose upon exposure to moisture.
Organic Peroxides: Materials that are normally stable, but can become unstable at
high temperatures and pressures. These materials may react with water, but will not
release energy. Explosives: Division 1.5 & 1.6 substances that are very insensitive
explosives or that do not have a mass explosion hazard. Compressed Gases:
Pressure below OSHA definition. Pyrophorics: No Rating. Oxidizers: Packaging
Group III; Solids
: any material that in either concentration tested, exhibits a mean
burning time less than or equal to the mean burning time of a 3:7 potassium
bromate/cellulose mixture and the criteria for Packing Group I and II are not met.
Liquids
: any material that exhibits a mean pressure rise time less than or equal to the
pressure rise time of a 1:1 nitric acid (65%)/cellulose mixture and the criteria for
Packing Group I and II are not met. Unstable Reactives: Substances that may
decompose, condense or self-react, but only under conditions of high temperature
and/or pressure and have little or no potential to cause significant heat generation or
explosive hazard. Substances that readily undergo hazardous polymerization in the
absence of inhibitors.); 2 (Water Reactivity: Materials that may react violently with
water. Organic Peroxides: Materials that, in themselves, are normally unstable and will
readily undergo violent chemical change, but will not detonate. These materials may
also react violently with water. Explosives: Division 1.4 – Explosive substances where
the explosive effect are largely confined to the package and no projection of fragments
of appreciable size or range are expected. An external fire must not cause virtually
instantaneous explosion of almost the entire contents of the package. Compressed
Gases: Pressurized and meet OSHA definition but < 514.7 psi absolute at 21.1°C
(70°F) [500 psig]. Pyrophorics: No Rating. Oxidizers: Packing Group II Solids
: any
material that, either in concentration tested, exhibits a mean burning time of less than or
equal to the mean burning time of a 2:3 potassium bromate/cellulose mixture and the
criteria for Packing Group I are not met. Liquids
: any material that exhibits a mean
pressure rise time less than or equal to the pressure rise of a 1:1 aqueous sodium
chlorate solution (40%)/cellulose mixture and the criteria for Packing Group I are not
met.